![Hydroxylapatite-338779](https://www.nationalelfservice.net/cms/wp-content/uploads/2022/02/Hydroxylapatite-338779-150x150.jpg)
This review of the efficacy of fluoride-free nano-hydroxyapatite agents (nHA) to enhance remineralisation or hamper demineralisation of enamel caries included 10 small studies. 5 studies were in-vivo and 5 in-situ but they were of short duration with 7 being at high risk of bias so provide very low certainty evidence. Additional high quality well reported studies are needed to assess nHA.
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