Antipsychotic effectiveness: the numbers don’t lie, check the scoreboard

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Students and Teachers from the King’s College London PNoMH Distance Learning MSc summarise a major new meta-analysis that brings together the last 60 years of placebo-controlled antipsychotic drug trials in acute schizophrenia.

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Peri-implantitis: little evidence that particular non-surgical treatments are better than debridement alone

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This Bayesian network meta-analysis only included 11 small studies of overall low quality. While the greatest reduction in PPD was seen with debridement in conjunction with antibiotics the difference are small so it is difficult to conclude that any particular non-surgical treatment for peri-implantitis performs better than debridement alone

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Combination therapies performed better than single ones for treating periodontal bony defects, but additional benefits were small

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A range of regenerative treatments have been used for the  treatment of periodontal infrabony defects. Guided tissue regeneration (GTR) and enamel matrix derivatives (EMD) are two popular treatment and they have both been used in combination with other treatment.   This network meta-analysis was conducted to assess the potential effects of the various combinations. Unlike a [read the full story…]