comorbidity

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Introduction

Comorbidity, or the co-occurrence of two distinct medical conditions, is a common phrase in both physical and mental health. Whilst the term was originally conceived to describe medical phenomena, the term was adopted by psychiatry in the description of more than one clinical presentation occurring simultaneously. However, its use in psychiatry is not without controversy. 

What we know already

Large-scale prevalence data can seemingly tell us much about the high rate of comorbidity in mental health. Data from US National Comorbidity Survey, for example, suggested that, of those reporting mental health difficulties (across a 12-month prevalence), only 55% carried a single psychiatric diagnosis.

One important area of recent research concerns the rates of comorbidity of physical and mental health difficulties, particularly in the area of chronic health conditions. Mental Elf blogs have reported that people with schizophrenia are significantly more likely to die from heart disease and cancer; while the National Schizophrenia Audit calls for improved monitoring of physical health in people with schizophrenia. We know that depression and anxiety are more common when a person has a chronic health problem, and this comorbidity leads to poorer clinical and quality of life outcomes. This has led to an increase in interventions targeting the psychological consequences of chronic ill health.

Areas of uncertainty

The controversy in psychiatric comorbidity is the issues of mutual exclusivity. We are not able to conclude as to whether ‘comorbid’ psychiatric diagnoses are separate clinical entities, or multiple features of the same underlying cause. This has led to much criticism of the term ‘psychiatric comorbidity’.

Furthermore, certain diagnostic labels, such as personality disorders, attract particular scrutiny, due to their high levels of comorbidity with other mental health diagnoses. Similarly, people often meet the criteria for more than one personality disorder. This again creates uncertainty as to the precise nature of the condition, or conditions, being diagnosed.

What’s in the pipeline?

The recent publication of the Diagnostic and Statistic Manual (DSM)-5 seemingly retains the notion that multiple distinct clinical diagnoses exist, thus maintaining the argument for psychiatric comorbidity. Alternative conceptualisations have been suggested, along dimensional models, such as ‘anxious-misery’, ‘externalising’ and ‘fear-based’ dimensions. However, these were not adopted in the DSM-5.

As our understanding of mental health conditions continues to improve, so too hopefully will our understanding of comorbidity, and its relevance to psychological and psychiatric phenomena.

References

First, M. B. (2005). Mutually exclusive versus co-occurring diagnostic categories: the challenge of diagnostic comorbidity. Psychopathology, 38, 206-210. [Abstract]

Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of general psychiatry, 62, 617-627. [Abstract]

Naylor, C., Parsonage, M., McDaid, D., Knapp, M., Fossey, M. and Galea, A. (2012) Long-term conditions and mental health: the cost of co-morbidities. The King’s Fund, London, UK. [Full text]

Acknowledgement

Written by: Patrick Kennedy-Williams
Reviewed by:
Last updated: Sep 2015
Review due: Sep 2016

Our comorbidity Blogs

Reducing cardiovascular risk in people with severe mental illness

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Masuma Mishu from the Closing the Gap Network reviews a recent US trial of a comprehensive cardiovascular risk reduction intervention in people with severe mental illness, which shows promising results.

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Autism and eating disorders: is it time to give the PEACE pathway a chance?

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Rachel Symons explores a new paper about the PEACE pathway (Pathway for Eating disorders and Autism developed from Clinical Experience), which hopes to increase understanding and improve care for patients with a dual diagnosis of autism and eating disorders.

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Walk this way: can a health coaching intervention increase physical activity in people with severe mental illness?

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Gordon Johnston and Michel Syrett prepare for the #HealthSMI event on 24th June by blogging about a recent pilot RCT of a health coaching intervention (Walk This Way) to reduce sedentary behaviour and increase physical activity in people with serious mental illness.

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Antipsychotics for schizophrenia: do they provide a longer, healthier life?

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Paul Heron from the Closing the Gap Network writes his debut blog about a 20‐year cohort study of physical morbidity and mortality in relationship to antipsychotic treatment in a huge group of people with schizophrenia in Finland.

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Transdiagnostic approaches to mental health: Keeping the baby and throwing out the bathwater

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Melissa Black and Tim Dalgleish summarise and critique a recent review on transdiagnostic psychiatry, which they feel presents an overly negative view of transdiagnostic approaches in mental health.

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Prevalence of comorbid personality disorder and alcohol use disorder

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People diagnosed with “personality disorders” are likely to also experience alcohol problems.

Dean Connolly summarises a recent systematic review that confirms the very high prevalence of comorbid personality disorders and alcohol use disorders.

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Autism and psychiatrists: experience, knowledge and attitudes revealed in new survey

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Eloise Stark looks at a recent online survey which seeks to understand psychiatrists’ knowledge, attitudes and experiences in identifying and supporting their patients on the autism spectrum.

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We know how to reduce premature deaths from co-morbid mental health and substance use problems, so why aren’t we doing anything about it?

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Ian Hamilton looks at a Swedish 42-year follow-up study, which looks at the impact that psychiatric comorbidity can have on premature death in a cohort of patients with substance use disorders.

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How can digital technology help close the mortality gap for people with severe mental illness?

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Lina Gega from the Closing the Gap Network explores a recent review of digital technology for health promotion, which looks at opportunities to address excess mortality in people living with severe mental illness.

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Higher body mass index is associated with a lower subjective wellbeing

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Benjamin Janaway explores a recent mendelian randomisation study that looks at the causal effects between subjective wellbeing and cardiometabolic health.

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