Ketamine “shows promise” as an anti-suicidal ideation agent, but will this promise ever be realised?

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Rosalind McAlpine and Karel Kieslich summarise a recent systematic review which focuses on the rapid anti-suicidal ideation effect of ketamine.

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Metacognitive therapy for depressive symptoms in cardiac patients: new findings from the PATHWAY trial

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Lydia Poole reviews a recent randomised controlled trial evaluating group metacognitive therapy for depression and anxiety in cardiac patients.

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Maintenance or discontinuation of antidepressants for depression? Findings from the ANTLER trial

For every 6 people stopping their medication there was one additional relapse compared to those who maintained their antidepressant treatment, suggesting that stopping medication has an increased risk of relapse.

Raphael Rifkin-Zybutz and Sameer Jauhar summarise the recently published ANTLER trial, which explores whether antidepressant maintenance can reduce the risk of relapse in depression.

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In children aged 4-5 with relatively poor language skills, the Nuffield Early Language Intervention improved their language scores

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Douglas Badenoch helps us prepare for another CAMHS Around the Campfire session by exploring a recent cluster RCT on early language screening and intervention using the Nuffield Early Language Intervention.

Follow #CAMHScampfire on Twitter at 5pm BST on Monday 13th September for an online journal club discussing this paper. Or sign up now to join the free webinar hosted by ACAMH.

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Can ketamine metabolites and gamma power help predict clinical response for ‘treatment resistant depression’?

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Anya Borissova summarises a recent randomised placebo-controlled trial that evaluated ketamine metabolites, clinical response, and gamma power for major depression.

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SlowMo: an app to improve thinking biases in people experiencing paranoia

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Imogen Bell blogs about a recent randomised controlled trial of the SlowMo app, which aimed to slow down thinking patterns and correct interpretation biases in people experiencing paranoia.

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The Care Ecosystem: telephone support to help people with dementia and their carers

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A UCL MSc group of students review a US randomised controlled trial of the ‘Care Ecosystem’; collaborative care for dementia delivered by telephone and internet, which suggests improvements in quality of life and caregiver well-being, and reductions in health service use.

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Turn on, or tune out? Is psilocybin assisted therapy close to becoming a first-line treatment for depression?

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James Rucker and Sameer Jauhar summarise a recent RCT on the effectiveness of psilocybin assisted therapy versus escitalopram assisted therapy for major depressive disorder.

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Could a decision support tool help to guide mental health treatment in primary care?

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Linda Gask reviews a recent randomised controlled trial on the clinical efficacy of a Decision Support Tool (Link-me) to “guide the intensity of mental health care in primary practice”.

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Ending self-stigma: not at all straightforward

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Dave Steele summarises a recent randomised controlled trial, which suggests that there may be benefit in self-stigma programmes for those with severe mental illness, but more work is needed.

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