New and emerging treatments for major depressive disorder

Sprouts of hope for treatment resistant depression?

Kirsten Lawson summarises a new ‘state of the art review’ in the BMJ which focuses on novel and emerging pharmacotherapy and neuromodulation for people with ‘treatment resistant depression’.

[read the full story...]

Using the highs to combat the lows: ketamine-assisted therapy for anxiety and depression

ketamine

In her debut blog, Gabrielle Williams reviews a US study on the safety and effectiveness of ketamine-assisted therapy (a digital intervention combining psychotherapy, journaling and ketamine) for moderate to severe anxiety and depression.

[read the full story...]

Ketamine and suicidal ideation: French trial finds modest short-term effects

Ketamine.,Ketamine,Pills,In,Rx,Prescription,Drug,Bottle

Anya Borissova reviews a French trial that claims to be evidence that “ketamine is rapid, safe in the short term, and has persistent benefits for acute care in suicidal patients”.

[read the full story...]

Ketamine “shows promise” as an anti-suicidal ideation agent, but will this promise ever be realised?

sinitta-leunen-aFXiQMUi2zA-unsplash

Rosalind McAlpine and Karel Kieslich summarise a recent systematic review which focuses on the rapid anti-suicidal ideation effect of ketamine.

[read the full story...]

Can ketamine metabolites and gamma power help predict clinical response for ‘treatment resistant depression’?

girl-with-red-hat-r4A-lJTgXQg-unsplash

Anya Borissova summarises a recent randomised placebo-controlled trial that evaluated ketamine metabolites, clinical response, and gamma power for major depression.

[read the full story...]

Patients’ experience of ketamine treatment for depression: the ‘Ketamine and me’ project

shutterstock_562050361

In her debut blog, Harmony Jiang reviews a recent qualitative study exploring patients’ experience and response to ketamine treatment for depression.

[read the full story...]

Intranasal esketamine for treatment-resistant depression: the first clinical study

shutterstock_174166007

Jodi Rintelman writes her debut elf blog on the first randomised controlled trial on the efficacy and safety of intranasal esketamine as an adjunctive treatment to antidepressants for treatment-resistant depression.

[read the full story...]

The antidepressant effects of ketamine are confirmed by a new systematic review and meta-analysis

shutterstock_18453376

Helge Hasselmann summarises a new systematic review and meta-analysis, which confirms the antidepressant effects of ketamine.

[read the full story...]

One new drug a week: club drugs and novel psychoactive substances

shutterstock_36627214

Meg Fluharty summarises a recent report from the Royal College of Psychiatrists and explores why novel psychoactive substances and club drugs need a different response from UK treatment providers.

[read the full story...]

Ketamine for depression: new review highlights the need for an RCT

Helge Hasselmann reviews a new systematic review of ketamine for depression, which highlights the need for an RCT to provide reliable data on the safety, tolerability and best route of administration.

[read the full story...]