Sedation for children undergoing dental treatment

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This Cochrane review update of the efficacy and relative efficacy of conscious sedation agents and dosages for behaviour management in paediatric dentistry includes 50RCTs providing some moderate-certainty evidence that oral midazolam is an effective sedative agent for children undergoing dental treatment.

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Intravenous midazolam sedation for dental treatment: review found no significant side effects

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This review of IV midazolam for treating children and adolescents only identified 11 studies (5 RCTs, 6 non randomised). No serious adverse events were reported but there was a generalised inconsistency in side effect reporting. Consequently the call for better side effect reporting.

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Largest RCT so far suggests that ketamine may be useful in the acute treatment of refractory depression

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Major depression is a serious mental illness that often does not respond to mainstream drug treatment (antidepressants). In addition, there is usually a delay of 2-6 weeks before mood improves significantly. In situations like this, when at least two conventional antidepressants have been tried without success, depression is considered treatment-resistant. While multiple different strategies to [read the full story…]

Significant side effects appear rare when using oral midazolam for behaviour management in children and adolescents requiring dental treatment

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Unfortunately dental caries remains a significant problem in children with some young children requiring multiple procedures. Traditionally this was managed with general anesthesia, increasingly sedation and behaviour management are seen as potential alternative approaches and a 2010 guideline from the National Institute for Health and Clinical Excellence (NICE) suggested that midazolam could be used for [read the full story…]