Jonathon Tomlinson considers his options as a GP supporting people with depression and complex needs, after reading a new systematic review and dose-response meta-analysis, which suggests that higher doses of antidepressants bring maximum side effects with only marginal gains.
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Elwira Lubos summarises the recent ATLAS RCT of antipsychotic treatment for very late-onset schizophrenia-like psychosis, which provides evidence for the effectiveness of a very low dose of Amisulpride (100 mg).
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This review of amoxicillin & metronidazole as an adjunct to non-surgical periodontal treatment included 18 trials . A small benefit was seen with antibiotic use but no clinically meaningful difference between different doses or duration of amoxicillin-plus-metronidazole at 3 months post-treatment.
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Sarah Knowles appraises a recent study of UK routine practice, which looks at the effect that duration of psychotherapy has on recovery and improvement rates.
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Andrew Shepherd summarises a meta-analysis, which looks at the dose equivalents of antidepressants by bringing together data from 83 trials of 23 different antidepressants.
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