Targeting inflammation in depression: a proof-of-concept worth following

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A single dose of tocilizumab cleared inflammation in depressed patients, but did it ease their symptoms? A proof-of-concept RCT with cautious promise.

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How sleep changes across later life, and what it means for mental health

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A large UK Biobank study tracked sleep in over 77,000 adults. Here’s what the data reveals about age, sex and mood.

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Anti-inflammatories for depression: targeting the right patients matters

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Decades of disappointing anti-inflammatory trials for depression may have failed because they weren’t targeting the right patients. New meta-analysis shows promising results when they do.

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Inside the diagnostic grey zone: using machine learning to separate bipolar and major depression

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High misdiagnosis rates between bipolar and major depressive disorder cause real harm to patients and services. This new neuroimaging study tested whether brain connectivity and machine learning could do a better job of telling the two apart, with interesting but limited results.

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Putting oil on the fire: Do people with high inflammation react differently to immune stress?

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Inflammation is a key factor in depression for many people. This new RCT used an experimental immune challenge to explore how individuals with high inflammation respond differently—shedding light on a distinct biological subtype of depression.

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Predicting antidepressant response using artificial intelligence

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Holly Fraser discusses new findings on whether and how we can predict antidepressant response using artificial intelligence.

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