Antipsychotic efficacy measured by real-world observational study

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Tracey Roberts examines whether a retrospective observational study accurately investigates the effectiveness of second and first generation antipsychotics.

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In praise of little: sponsorship bias in depression research

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Samei Huda welcomes a new meta-analysis of sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression.

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CBT for Autism Spectrum Disorders and comorbid mental illness

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Alix Dixon presents a recent systematic review on the effectiveness of CBT for autism spectrum disorders and comorbid anxiety or depression.

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Acupuncture for mild cognitive impairment: rubbish in, rubbish out

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Edzard Ernst shines a light on the unfounded claims presented in a meta-analysis published today on acupuncture for amnestic mild cognitive impairment.

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Is the NICE guideline for bipolar disorder biased in favour of psychosocial interventions?

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Guy Goodwin reviews a new paper in the Lancet Psychiatry by Jauhar, McKenna and Laws, that calls into question the trustworthiness of the NICE bipolar disorder guidance.

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The PACE Trial for chronic fatigue syndrome: choppy seas but a prosperous voyage

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Simon Wessely responds to the huge amount of recent criticism that has surrounded the publication of a follow-up paper of the PACE trial into chronic fatigue syndrome. This extended blog presents the PACE trial and its main results, but also reminds us what makes a good RCT, as well as exploring how well PACE measures up.

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Antidepressant meta-analyses: big business and bias

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Alex Langford reflects on the findings of a recent study that looks at 185 meta-analyses of antidepressants. It finds that industry involvement in research can lead to biased studies that under-report negative aspects of antidepressants for depression.

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Mental health research: let us reason together #RCTdebate

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Amy Price and Douglas Badenoch respond to the McPin Foundation talking point paper written by Alison Faulkner entitled ‘Randomised controlled trials: The straitjacket of mental health research?’

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