The PACE Trial for chronic fatigue syndrome: choppy seas but a prosperous voyage

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Simon Wessely responds to the huge amount of recent criticism that has surrounded the publication of a follow-up paper of the PACE trial into chronic fatigue syndrome. This extended blog presents the PACE trial and its main results, but also reminds us what makes a good RCT, as well as exploring how well PACE measures up.

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Antidepressant meta-analyses: big business and bias

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Alex Langford reflects on the findings of a recent study that looks at 185 meta-analyses of antidepressants. It finds that industry involvement in research can lead to biased studies that under-report negative aspects of antidepressants for depression.

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Mental health research: let us reason together #RCTdebate

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Amy Price and Douglas Badenoch respond to the McPin Foundation talking point paper written by Alison Faulkner entitled ‘Randomised controlled trials: The straitjacket of mental health research?’

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