Orthognathic surgery: limited evidence on antibiotic prophylaxis?

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2 reviews and 2 RCTs were discussed in this review of the effect of antibiotics on postoperative infections in orthognathic surgery. There is a lack ofclarity on the preferred antibiotic and the optimal duration of administration.

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Infective endocarditis prophylaxis – NICE reaffirms 2008 guidance

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NICE has completed a review of its 2008 guidance on antimicrobial prophylaxis against infective endocarditis following the publication of a recent study. NICE found no need to change any of its existing guidance.

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Antibiotic prophylaxis and dental implant failure

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This review of antibiotic prophylaxis during dental implant placement considered both systematic reviews and RCTs. Evidence from the 10 included RCTs suggests a small reduction (2%) in the risk of implant loss. These results are similar to a recent Cochrane review.

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Prosthetic joints: prophylactic antibiotics not recommended before dental procedures

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The latest recommendation from the ADA indicates that prophylactic antibiotics are not needed for patients with prosthetic joints undergoing dental treatments. The finding are based on 4 case-controlled trials that are considered to provide moderate evidence of no association.

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Orthognathic surgery: antibiotic prophylaxis reduced surgical site infection

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This new Cochrane review identified 11 RCTs and suggests that for those undergoing orthognathic surgery, long term antibiotic prophylaxis decreased the risk of surgical site infection compared with short-term regimens.

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Dental implant failures reduced with prophylactic antibiotic suggests review

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This new review covers similar ground to the 2013 Cochrane review. It includes non-randomised controlled trials, but as with the Cochrane review the findings suggest that antibiotics reduce early implant failure.

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Antibiotic prophylaxis in surgery – SIGN Guideline 104

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The Scottish Intercollegiate Guidelines Network  (SIGN) has just launched their updated guideline on antibiotic prophylaxis in surgery.  SIGN’s first guideline of this topic (SIGN 45)  was published in 2000 and updated in 2008.  The guideline does not aim to provide every surgical speciality with a comprehensive text on preventing  surgical site infection (SSI), but rather [read the full story…]

No evidence on whether antibiotic prophylaxis is effective or ineffective against bacterial endocarditis in people at risk who need invasive dental procedures

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Bacteraemia is common following dental procedures and it was believed that this could lead to bacteria endocarditis a severe infection of the lining of the chambers of the heart with a high mortality rate.  Until 2008 when National Institute for Health and Care Excellence (NICE) recommended that antibiotics were not required guidelines in many countries [read the full story…]