Orthognathic surgery: limited evidence on antibiotic prophylaxis?

The authors sought to review available literature relating to SSRI withdrawal syndromes

2 reviews and 2 RCTs were discussed in this review of the effect of antibiotics on postoperative infections in orthognathic surgery. There is a lack ofclarity on the preferred antibiotic and the optimal duration of administration.

[read the full story...]

Non-surgical periodontal therapy – which antibiotic regime?

shutterstock_64158991 question mark pills tablets

This review of amoxicillin & metronidazole as an adjunct to non-surgical periodontal treatment included 18 trials . A small benefit was seen with antibiotic use but no clinically meaningful difference between different doses or duration of amoxicillin-plus-metronidazole at 3 months post-treatment.

[read the full story...]

Periodontitis- supportive periodontal treatment

shutterstock_2584741

This Cochrane review of the effects of supportive periodontal therapy (SPT) in the maintenance of the dentition of adults treated for periodontitis included 4 RCTs providing is insufficient evidence to determine the superiority of different protocols or adjunctive strategies to improve tooth maintenance during SPT.

[read the full story...]

Nonsurgical periodontal treatment: adjunctive antibiotic use in diabetics

Participants ranked the clinical instruments most highly

This review of adjunctive use of systemic antibiotics in nonsurgical periodontal treatment of diabetics identified 12 small RCTs. No additional benefit was seen with antibiotic use

[read the full story...]

Antibiotics as an adjunct to the non-surgical periodontal treatment of smokers

Smoking man

Mark-Steven Howe looks at a systematic review of the effectiveness of adjunctive antibiotics in smokers undergoing non-surgical periodontal treatment. While a statistical benefit was noted it was not considered to be clinically relevant.

[read the full story...]

Third molar removal: antibiotics reduced risk of dry socket

shutterstock_133048361

This review of antibiotic prophylaxis for the removal of third molars included 22 RCTs and suggest that antibiotic use lowered the infection risk by 60%. The number pf patients needed to treat to prevent one infection was 14 (95%CI;11-19).

[read the full story...]

Periodontal treatment- adjuvant antibiotics for diabetic patients?

shutterstock_2584741

This review of adjuvant antibiotics for diabetics undergoing periodontal treatment included 13 small RCTs. While a statistically significant improvement in probing depth was seen the magnitude of this improvement is unlikely to be clinically significant.

[read the full story...]

Bisphosphonate-related osteonecrosis of the jaw treatments– little evidence available

bisphosphonate

This Cochrane review of bisphosphonate related osteonecrosis of the jaw only identified one small RCT. The trial compared the use of hyperbaric oxygen (HBO) as an adjunct to standard care. While it suggested a benefit for HBO it was under powered and at high riisk of bias

[read the full story...]

Third molars: single dose of preoperative antibiotic reduced infection

shutterstock_31846396

10 RCTs were included in this review of preoperative antibiotics for removal of third molars. The use of antibiotics significantly reduced the odds of surgical site infection or alveolar osteitis (OR = 0.30; 95% CI, 0.19 to 0.47; P≤.00001)

[read the full story...]

Little evidence for antibiotic use in irreversible pulpitis

shutterstock_64158991 question mark pills tablets

This is the latest update of this Cochrane review of the effectiveness of antibiotics for irreversible pulpitis. Only 1 small RCTs is available which provides insufficient evidence to determine whether antibiotics reduce pain or not compared to not having antibiotics

[read the full story...]