Aloe vera for treatment of oral submucous fibrosis?

shutterstock_32414035 - Betel leaf

This review effectiveness of aloe vera on alleviating the symptoms of oral submucous fibrosis included 6 RCTs . The findings suggest a possible benefit but 5 of the trials were at high risk of bias so the findings should be viewed cautiously.

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Oral lichen planus and diabetes: are they associated?

Lichen_planusWickham's

This review of the relationship between oral lichen planus and diabetes included 22 studies. While both meta-analysis suggest a relationship the confidence intervals cross the line of no effect so are not statistically significant.

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Sjögren’s syndrome: treatments for dry mouth and hyposalivation

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36 studies were included in this review of treatment options for xerostomia, hyposalivation and quality of life in patients with Sjögren’s syndrome provinding evidence to support pilocarpine use. However the number of studies were limited and adverse effects were common.

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Geographic tongue: little evidence for the management of symptomatic cases

oral_lichen

This review of treatments for the management of symptomatic benign migratory glossitis (BMG) only included 11 small low quality studies providing little evidence for the management of symptomatic BMG.

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Oral lichen planus: Rate of malignant transformation

Lichen_planusWickham's

This review of the malignant transformation rate (TR) of oral lichen planus included 21 observational studies the majority of which were retrospective. The overall estimate of TR was 1.4%.

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Mucositis in adult cancer patients reduced with keratinocyte growth factor

PDB_1qql_EBI

This Cochrane review of cytokines and growth factors for preventing oral mucositis in patients having cancer treatment included 35 RCTs finding keratinocyte growth factor beneficial in the prevention of oral mucositis .

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Hepatitis C and oral lichen planus

HCV

This review of the association between hepatitis C virus (HCV) and oral lichen planus (OLP) identified 19 case-controlled studies. While a 6-fold increase in risk of HCV infection was noted in OLP patients a majority of the studies took place in areas with high endemic HCV rates and there is some concern regarding publication bias and the quality of the available studies.

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Laser therapy for oral lichen planus

Lichen_planusWickham's

This review comparing low level laser therapy (LLLT) with steroids for the treatment of oral lichen planus only identified 5 studies none of which were at low risk of bias. Further high quality trials are needed to assess the efficacy of LLLT.

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Denture stomatitis: some evidence for nystatin and disinfecting agents

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This review of interventions for the management of denture stomatitis identified 35 RCTs. A majority of the RCTs were at high risk of bias. The findings suggest that nystatin and disinfecting agents have a positive effect but the results should be viewed cautiously because of the quality of the available evidence

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Oral mucositis in cancer patients: no benefit from chlorhexidine mouthwash

shutterstock_20760106 - mouthwash

This review of chlorhexidine (CHX) for prevention & treatment of oral mucositis included 12 RCTs with 9 contribution to the meta-analysis. CHX was not significantly effective in preventing mucositis or reducing its severity.

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