In this blog Manàs Dave looks at a systematic review of treatment options for patients with Burning Mouth Syndrome (BMS). Study heterogeneity means that only a narrative summary was possible so there is a need for high quality research in this area.
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This review looked at the efficacy of photodynamic therapy (PDT) for the treatment or oral lichen lplanus (OLP) and compares PDT with steroid therapy. 16 studies were included with the findings suggesting that photodynamic therapy may offer patients with OLP improved pain relief and better efficacy compared to topical corticosteroids.
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Manas Dave considers this review of the safety and reliability of digital pathology. The review included 24 studies showing high concordance between digital pathology and light microscopy suggesting that digital pathology is a viable alternative to light microscopy.
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In his first blog for the Dental Elf Rajpal Tattar take a look at a review of the diagnostic accuracy of salivary biomarkers for the detection of oral squamous cell carcinoma (OSCC). The review considers two biomarkers, cytokeratin 19 fragment (CYFRA 21-1) and for matrix metalloproteinase-9 (MMP-9) but there is no conclusive evidence for either at present.
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This review of metastasis to the oral and maxillofacial region included 217 studies (190 case reports,24 case series ). Metastasis were uncommon, but identified from 29 primary sites, the most common sites being lung the lungs (20.97%), breast (12.06%) and kidney (11.78%).
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Manas Dave looks at a recent review of which considers the efficacy of optical fluorescence imaging as an adjunct to clinical oral examination for the detection of oral mucosal lesions. The review includes 27 studies and provides evidence to support additional high quality studies to assess its effectiveness.
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Manas Dave takes a look at this review evaluating the prophylactic and therapeutic effects of low-level laser therapy (LLLT) in patients who might or have developed oral mucositis during chemotherapy or radiotherapy.
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This review assessing the evidence of the impact of replacing missing teeth with dentures on the development of osteoradionecrosis in patients who have radiotherapy for head and neck cancer only identified 3 case-controlled studies of very low quality.
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In this blog Manás Dave looks at a review of the prevalence of human papilloma virus (HPV) in oral potentially malignant disorders (OPMD). Although 52 studies were included one in five OPMDs being HPV positive is not a substantial link so teh findings need to be interpreted cautiously.
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Marianne Dobson takes a look at this systematic review of the orofacial manifestations of systemic lupus erythematosus (SLE). The review included 30 studies and provides a narrative summary of a issues related to orofacial symptoms and management. However good quality prospective studies are needed to improve the the quality of evidence surrounding this topic.
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