Human Papilloma Virus in oral potentially malignant disorders

Human Papilloma Virus

In this blog Manás Dave looks at a review of the prevalence of human papilloma virus (HPV) in oral potentially malignant disorders (OPMD). Although 52 studies were included one in five OPMDs being HPV positive is not a substantial link so teh findings need to be interpreted cautiously.

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Systemic Lupus Erythematosus: What are the orofacial manifestations and dental considerations?

Lupus (SLE)

Marianne Dobson takes a look at this systematic review of the orofacial manifestations of systemic lupus erythematosus (SLE). The review included 30 studies and provides a narrative summary of a issues related to orofacial symptoms and management. However good quality prospective studies are needed to improve the the quality of evidence surrounding this topic.

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Oral Proliferative Verrucous Leukoplakia: What are the clinical features?

Leukoplakia , Verrucous

Marianne Dobson in her first blog for the Dental Elf takes a look at a systematic review looking at the main clinical features of proliferative verrucous leukoplakia

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Oral lichen planus: How common is it worldwide?

Lichen Planus -histopathology

This review of the global prevalence of oral lichen planus (OLP) included 66 observational studies providing an estimate of prevalence of 1.01% (0.74 to 1.32%).

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Oral submucous fibrosis: Is treatment with hyaluronidase and corticosteroids effective?

A_close_up_of_Areca_nut

This review of the efficacy of hyaluronidase combined with corticosteroids in the management of oral submucous fibrosis (OSF)included 6 small RCTs of short duration. Only one of the RCTs was considered to be at low risk of bias so additional well conducted and reported studies with larger sample are needed to evaluate treatments for OSF.

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Oral leukoplakia: Malignant transformation rate

OLYMPUS DIGITAL CAMERA

This review of the rate of malignant transformation of oral leukoplakia included 34 many retrospective observational studies. The estimated mean malignant transformation rate was 9.7% (95%CI; 7.8% to 11.7%).

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Oral candidiasis: Are probiotics effective?

Candida albicans

This review of the the efficacy of probiotics on oral Candida spp. includes 12 RCTs and suggests a possible benefit. However the quality of the evidence is limited so the findings should be intepreted cautiously.

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Oral lichen planus: malignant transformation rate

Lichen_planusWickham's

This review of the malignant transformation rate of oral lichen planus and associated risk factors included 33 studies. Using a strict definition the authors found a malignant transformation rate of 0.44%.

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Oral Lichen Planus: Is treatment with corticosteroids safe and effective?

Lichen_planusWickham's

This Cochrane review of the efficacy and safety of corticosteroids for the treatment of people with oral lichen planus(OLP) included 35 RCTs suggesting that they may be more effective than placebo for reducing the pain of symptomatic OLP but the reliability of the finding is low.

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Vitamin D deficiency: Is it a risk factor for recurrent aphthous stomatitis?

Researchers in this study wanted to see if people with learning disabilities had higher levels of vitamin D deficiency than the general population

This review of a possible association between vitamin D deficiency and recurrent aphthous stomatitis (RAS) included 5 case control studies providing limited evidence that low levels of serum vitamin D might be a risk factor for RAS.

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