Chronic ulcerative stomatitis: Clinical and immunological features

Direct immunoflorescence

In this blog Iris Vaid looks at a review of chronic ulcerative stomatitis (CUS) a rare mucous membrane condition that presents clinically as non-specific ulcerated or erosive lesions. The review included 81 cases reported in 25 papers.

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Comparison of topical antifungal agents for oral candidiasis treatment

Candida_Gram_stain

This review comparing the efficacy and safety of topical antifungal drugs for oral candidiasis in children and adults included 11 RCTs 9 of which concerned adults and 2 children. The findings support the use of fluconazole and amphotericin B for adults.

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Adverse effects of E-cigarettes on head, neck, and oral cells

e-cigarette

Iris Vaid takes a look at this review of whether e-cigarettes have a negative impact on the cells in the head, neck, and mouth. 16 in-vitro studies showed that oral cells exposed to e-cigarettes showed aberrant cell morphology, reduced cell viability, and increased apoptosis and/or necrosis.

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Medication-related osteonecrosis of the jaw (MRONJ): Prevention and treatment

osteonecrosis

This Cochrane review update of interventions for the prevention or treatment of medication-relatesd osteonecrosis of the jaw (MRONJ) included 13 RCTs. However the studies provided insufficient to either claim or refute a benefit of the interventions tested for prophylaxis or treatment of MRONJ.

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Salivary lactate dehydrogenase in oral and potential malignant disorders

Study findings suggest a number of uses for visual aid support of Thickness Indicator Model tubes

In her first Dental Elf blog Iris Vaid looks at a review of salivary lactate dehydrogenase (LDH) as a potential diagnostic marker for oral cancer and oral potentially malignant disorders.

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Photodynamic therapy for denture stomatitis

shutterstock_28911784 False teeth

This review of comparing photodynamic therapy (PDT) and antifungals or the treatment of denture stomatitis included 5 studies involving a total of 218 patients. While the findings suggest that PDT is effective none of the the studies was at low risk of bias and the treatment protocols investigated differ.

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Medication‐related osteonecrosis of the jaw and non-antiresorptive medications

osteonecrosis

This review of the association between non-antiresorptive medications and medication‐related osteonecrosis of the jaw (MRONJ) included 70 studies. A majority of the studies (77%) were case series and the quantity and quality of the evidence is low so the findings should be interpreted cautiously.

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Malic acid spray for treating xerostomia

shutterstock_44704711

This review of the efficacy of topical sialogogue spray containing malic acid 1% for treating xerostomia included 5 RCTs involving 244 patients. While the findings suggested a benefit the available studies are small, of short duration and none are at low risk of bias.

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Early detection of oral cancer and oral potentially malignant disorders

shutterstock_72423985

This Cochrane review update of the diagnostic test accuracy of conventional oral examination, vital rinsing, light-based detection, mouth self-examination, remote screening, and biomarkers, used singly or in combination, for the early detection of OPMD or OSCC in apparently healthy adults included 18 studies.

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Oral lichen planus and malignant transformation

Lichen_planus

This review of high quality studies of oral lichen planus malignant transformation rate included 10 observational studies. The findings found a higher level of malignant transformation in higher quality studies 2.28% (95%CI; 1.49 to 3.20) compared with reviews including lower quality studies 1.14% (0.84 to 1.49).

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