This review effectiveness of aloe vera on alleviating the symptoms of oral submucous fibrosis included 6 RCTs . The findings suggest a possible benefit but 5 of the trials were at high risk of bias so the findings should be viewed cautiously.
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This review of the relationship between oral lichen planus and diabetes included 22 studies. While both meta-analysis suggest a relationship the confidence intervals cross the line of no effect so are not statistically significant.
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36 studies were included in this review of treatment options for xerostomia, hyposalivation and quality of life in patients with Sjögren’s syndrome provinding evidence to support pilocarpine use. However the number of studies were limited and adverse effects were common.
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This review of treatments for the management of symptomatic benign migratory glossitis (BMG) only included 11 small low quality studies providing little evidence for the management of symptomatic BMG.
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This review of the malignant transformation rate (TR) of oral lichen planus included 21 observational studies the majority of which were retrospective. The overall estimate of TR was 1.4%.
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This Cochrane review of cytokines and growth factors for preventing oral mucositis in patients having cancer treatment included 35 RCTs finding keratinocyte growth factor beneficial in the prevention of oral mucositis .
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This review of the association between hepatitis C virus (HCV) and oral lichen planus (OLP) identified 19 case-controlled studies. While a 6-fold increase in risk of HCV infection was noted in OLP patients a majority of the studies took place in areas with high endemic HCV rates and there is some concern regarding publication bias and the quality of the available studies.
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This review comparing low level laser therapy (LLLT) with steroids for the treatment of oral lichen planus only identified 5 studies none of which were at low risk of bias. Further high quality trials are needed to assess the efficacy of LLLT.
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This review of interventions for the management of denture stomatitis identified 35 RCTs. A majority of the RCTs were at high risk of bias. The findings suggest that nystatin and disinfecting agents have a positive effect but the results should be viewed cautiously because of the quality of the available evidence
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This review of chlorhexidine (CHX) for prevention & treatment of oral mucositis included 12 RCTs with 9 contribution to the meta-analysis. CHX was not significantly effective in preventing mucositis or reducing its severity.
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