Osteoradionecrosis of the jaws: Prevention in adult patients with head and neck cancer

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This Cochrane review of interventions for preventing osteoradionecrosis of the jaws in adults with head and neck cancer undergoing curative or adjuvant (i.e. non-palliative) radiotherapy included 4 RCTs. The limited quality of the available studies means evidence regarding the interventions evaluated in this review is uncertain.

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Bisphosphonate-related osteonecrosis of the jaw treatments– little evidence available

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This Cochrane review of bisphosphonate related osteonecrosis of the jaw only identified one small RCT. The trial compared the use of hyperbaric oxygen (HBO) as an adjunct to standard care. While it suggested a benefit for HBO it was under powered and at high riisk of bias

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Bisphosphonate-related osteonecrosis of the jaw treatments

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97 papers describing 4879 cases of bisphosphonate-related osteonecrosis were included in this review. A wide range of management approaches were identified but the quality of the available evidence is limited.

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Some weak evidence that hyperbaric oxygen treatment may improve outcomes for bisphosphonate-related osteonecrosis of the jaw

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Bisphosphonate-related osteonecrosis of the jaw (BONJ) is a recently recognised condition with reports  surfacing in  2003.  BONJ defined as exposed, necrotic bone in the maxilla or mandible that has persisted for more than eight weeks in patients taking bisphosphonates and where there has been no history of radiation therapy to the jaw.   It has been [read the full story…]