Adele Framer

Profile photo of Adele Framer
Adele is retired from information systems design and resides in California, USA. She has personal experience with antidepressant withdrawal syndrome, having suffered 11 years of protracted symptoms after going off 10mg paroxetine in 2004. As a lay researcher in the topic ever since, she is the author of a paper published in 2021 that has garnered more than 91,000 views, What I have learnt from helping thousands of people to taper off antidepressants and other psychotropic medications. Adele founded the peer support website in March 2011. With more than 18,000 registrations and 600,000 page views per month, among its 500,000 posts are 6,000 longitudinal case histories by patients, more than 60 drug-specific tapering topics and explanations of titration methods, and a gradual 10% per month hyperbolic tapering method self-guided by the patient. The site content is widely shared on Facebook and other websites and has been the basis for several scholarly articles.


Follow me here –

Antidepressant withdrawal or depression relapse? International guidelines on antidepressant discontinuation are unclear


Adele Framer summarises a systematic review which finds that major guidelines on antidepressant discontinuation only give clinicians vague guidance on distinguishing withdrawal from relapse.

[read the full story...]

Antidepressant discontinuation and continuation: new Cochrane review finds miasma of confound


Adele Framer, Founder of, explores a recent Cochrane review on antidepressant discontinuation versus continuation for adults with depression or anxiety, which highlights huge uncertainty in the science about antidepressant withdrawal.

[read the full story...]