Adele Framer

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Adele is retired from information systems design and resides in California, USA. She has personal experience with antidepressant withdrawal syndrome, having suffered 11 years of protracted symptoms after going off 10mg paroxetine in 2004. As a lay researcher in the topic ever since, she founded the peer support website in March 2011, which was designed to collect case histories. With more than 15,000 registrations and 500,000 page views per month, among its 500,000 posts are 6,000 naturalistic longitudinal case histories by patients. It provides more than 60 drug-specific tapering topics and explanations of titration methods, presenting a gradual 10% per month hyperbolic tapering method self-guided by the patient. The site content is widely shared on Facebook and other websites and has been the basis for several scholarly articles.


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Antidepressant discontinuation and continuation: new Cochrane review finds miasma of confound


Adele Framer, Founder of, explores a recent Cochrane review on antidepressant discontinuation versus continuation for adults with depression or anxiety, which highlights huge uncertainty in the science about antidepressant withdrawal.

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