Manas Dave

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Manas Dave is an NIHR Academic Clinical Fellow in Oral and Maxillofacial Pathology and Honorary Lecturer in Dentistry at The University of Manchester. Manas graduated from the University of Manchester with degrees in Pathology and Dentistry before undertaking General Professional Training in the North East. During this time, he achieved qualifications in Pathology Informatics and Medical Education. He is currently studying a Masters degree in Dental Public Health.

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Head and neck soft tissue sarcomas

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This review of the distribution of histological subtypes, treatment and overall survival (OS) rates of head and neck sacomas included 8 studies from 6 countries. Meta-analysis (5 studies) found the 5-year OS = 74%(95%CI; 63 to 84%)

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Diagnostic accuracy of salvia tests for SARS-CoV-2

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This review of the use and diagnostic accuracy of saliva tests for the detection of SARS-CoV-2 included 16 studies. THe findings suggests good diagnostic accuracy but furteher research is needed to determine confounding factors such as method and time of sample collection, transport medium, storage etc. prior to population testing.

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Interventions for oral lichen planus

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This systematic review and network meta-analysis comparing interventions for the management of oral lichen planus included 55 RCTs. While the findings suggested that topical corticosteroids may be most effective the evidence is of low to very low certainty.

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MicroRNAs for diagnosis of squamous cell carcinoma

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Manas Dave looks at a review of the diagnostic accuracy of blood and salivary microRNAs (miRNAs) in discriminating oral squamous cell carcinoma. The review included 20 cross-sectional studies and suggested moderate diagnostic accuracy and higlights a potential are for larger scale studies.

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Diabetes and dental implants

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This review of the possible association between diabetes mellitus and dental implant complications included 10 cohort studies (8 prospective 2 retrospective). The findings suggest that patients with diabetes are more likely to have clinical complications with dental implants.

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Detecting SARS-CoV-2 in Saliva

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This review of the use of as a sample for the detection of SARS-COV-2 included 22 studies ( 2 case reports, 17 case series and 3 mass screenings) while SARS-CoV-2 is detected in saliva additional high quality studies are needed to determine efficacy.

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Recurrent aphthous stomatitis and serum zinc levels

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This review of the potential association between zinc levels and occurrence of Recurrent aphthous stomatitis (RAS) included 19 case-controlled studies. The findings show a sigificant association between low zinc levels and RAS.

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Oral manifestations of COVID-19

Covid-19

This review of the oral signs and symptoms in patients with COVID-19 includes 40 studies (33 cross-sectional and 7 case reports). The findings show a significant association with taste disorders but little in relation to other oral disorders. As this is planned to be a living review it will be interesting to see if further evidence emerges.

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Humoral immune response to SARS-CoV-2 in Iceland

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In another one of our Covid-19 blogs Manas Dave looks at an intersting study from Iceland looking at the changes in antibody levels within the first 4 months after SARS-CoV-2 infection.

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Treatment modalities in burning mouth syndrome

Depression

In this blog Manàs Dave looks at a systematic review of treatment options for patients with Burning Mouth Syndrome (BMS). Study heterogeneity means that only a narrative summary was possible so there is a need for high quality research in this area.

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