Chemotherapy for oral cavity and oropharyngeal cancer

Chemotherapy

This review of whether chemotherapy, in addition to radiotherapy and/or surgery for oral cavity and oropharyngeal cancer, results in improved overall survival included 100 studies. the findings indicated some benefit only when used in a few specific circumstances.

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Oral cryotherapy for preventing oral mucositis during chemotherapy

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This review of the efficacy of oral cryotherapy in the prevention of chemotherapy-induced oral mucositis included 14 studies and a total of 1577 patients. The findings indicate that oral cryotherapy is effective in preventing oral mucositis in patients undergoing chemotherapy for the management of solid malignancies.

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Low-level laser therapy in the prevention and treatment of oral mucositis

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Manas Dave takes a look at this review evaluating the prophylactic and therapeutic effects of low-level laser therapy (LLLT) in patients who might or have developed oral mucositis during chemotherapy or radiotherapy.

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Hypomineralisation and drugs used during pregnancy and infancy

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Manas Dave looks at this systematic review of the association between hypomineralised second primary molars (HSPM) and drug use during pregnancy and the first year of life

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Oral mucositis in cancer patients: the effect of oral supplementation

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This review of of the effects of oral supplementation on the prevention and/or treatment of oral mucositis in patients with cancer undergoing chemotherapy and/or radiotherapy included 12 RCTs and suggest that Zinc supplements may be beneficial.

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Oral Mucositis: can honey reduce its severity?

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This review of the use of honey to educe the severity of radio/chemotherapy-induced oral mucositis identified 7 low quality RCTs that suggest that use of honey may reduce the severity of oral mucositis.

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Oral cryotherapy reduces oral mucositis in patients receiving 5FU-based treatment for solid cancers

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This Cochrane review looked at cryotherapy (ice chips) for preventing oral mucositis in patients with cancer. 14 RCTS involving 1280 patients were included providing evidence that oral cryotherapy leads to large reductions in oral mucositis of all severities in adults receiving 5FU for solid cancers. However there was less confidence confident in the ability of oral cryotherapy to reduce oral mucositis in adults receiving high-dose melphalan before haematopoietic stem cell transplantation (HSCT).

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Oral cancer- monoclonal antibodies combined with standard treatment may improve outcomes

radiotherapy

12 trials were included in this Cochrane review of molecularly targeted therapies and immunotherapies as adjuncts to standard treatments for oral cancer. Moderate evidence was found that standard therapy plus epidermal growth factor receptor monoclonal antibody (EGFR mAb) reduced mortality and locoregional failures.

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Using ice chips reduces oral mucositis in patients undergoing chemotherapy

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Cancer treatment is increasingly effective but is associated with short and long term side effects. Oral side effects remain a major source of illness despite the use of a variety of agents to prevent them. One of these side effects is oral mucositis (mouth ulcers). The aim of this study was to assess the effect [read the full story…]