Salivary biomarkers CYFRA 21-1 and MMP-9 for oral squamous cell carcinoma diagnosis?

shutterstock_120437533

In his first blog for the Dental Elf Rajpal Tattar take a look at a review of the diagnostic accuracy of salivary biomarkers for the detection of oral squamous cell carcinoma (OSCC). The review considers two biomarkers, cytokeratin 19 fragment (CYFRA 21-1) and for matrix metalloproteinase-9 (MMP-9) but there is no conclusive evidence for either at present.

[read the full story...]

Optical fluorescence imaging in oral cancer and potentially malignant disorders

leukoplakia

Manas Dave looks at a recent review of which considers the efficacy of optical fluorescence imaging as an adjunct to clinical oral examination for the detection of oral mucosal lesions. The review includes 27 studies and provides evidence to support additional high quality studies to assess its effectiveness.

[read the full story...]

Oral Cancer – Referral by primary care doctors and dentists

jonathan-borba-iWkA_RzRLuY-unsplash

This review comparing primary care doctors and dentists in the referral of oral cancer included 22 mainly retrospective studies. Doctors refered sliightly more than dentists, typically 50% compared with 40% respectively.

[read the full story...]

Elective neck dissection versus observation for T1-2 oral squamous cell carcinoma

Severe_dysplasia

Manas Dave looks at a review of elective neck dissection (END) versus observation for the management of T1-2 oral squamous cell carcinoma. The review included 41 studies only 5 were RCTs the remainder being retrospective studies.

[read the full story...]

Oral lichen planus: malignant transformation rate

Lichen_planusWickham's

This review of the malignant transformation rate of oral lichen planus and associated risk factors included 33 studies. Using a strict definition the authors found a malignant transformation rate of 0.44%.

[read the full story...]

Elective neck dissection for early stage oral cancer?

leukoplakia

This UK multi-centre RCT of elective neck dissection(END) for early stage oral cancer found higher rates for overall and disease free survival in those patients having END.

[read the full story...]

Toombak: A risk factor for oral leukoplakia and cancer

29 September 2013. El Fasher: A trader shows a tray with tombac (chewing tobacco) at the market in El Fasher, North Darfur. Tombac is one of North Darfur’s major cash crops. The traditional markets for tombac include South Sudan, Blue Nile and South Kordofan states. Farmers assure four million people in Darfur are dependent on the cultivation and sale of tobacco. They claim that tobacco had been produced in the region since 1850.  Originally, the production of tombac started in Tombouctou (Mali) and later it was imported to Egypt and Darfur.  Photo by Albert González Farran, UNAMID

This review of the association between toombak use and oral leukoplakia and oral squamous cell carcinoma included 8 observational studies suggesting a strong association.

[read the full story...]

Oral Cancer: Elective neck dissection or watch and wait?

Bariatric surgery and marked weight loss is likely to improve knee complaints but there is a need for high quality studies

There is an ongoing debate about the management of patients with oral cavity squamous cell carcinoma and clinically negative cervical lymph nodes. Some clinicians favour preventive elective neck dissection (END) which although is linked with favourable survival has an adverse effect on quality of life while others adopt a wait and watch policy. The aim [read the full story…]

Oral mucositis in cancer patients: the effect of oral supplementation

shutterstock_74662099 zinc

This review of of the effects of oral supplementation on the prevention and/or treatment of oral mucositis in patients with cancer undergoing chemotherapy and/or radiotherapy included 12 RCTs and suggest that Zinc supplements may be beneficial.

[read the full story...]