Radiotherapy and dental implant survival

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This review assessing the effect of radiotherapy on the survival of dental implants in patients with head and neck cancer included 7 studies involving a total of 441 patients. implant survival rate was lower in irradiated patients with odds ratio = 4.77 (95%CI; 2.57 to 8.89) based on 4 studies.

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Salivary lactate dehydrogenase in oral and potential malignant disorders

Study findings suggest a number of uses for visual aid support of Thickness Indicator Model tubes

In her first Dental Elf blog Iris Vaid looks at a review of salivary lactate dehydrogenase (LDH) as a potential diagnostic marker for oral cancer and oral potentially malignant disorders.

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Tooth extraction prior to head and neck radiotherapy and osteoradionecrosis risk

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28 mainly retrospective studies were included in this review which aimed to determine if tooth extraction prior to head and neck radiotherapy (RT )is associated with a reduced risk of developing osteoradionectosis (ORN). The findings showed a significant association of post-RT dental extractions with the risk of ORN development, odds ratio = 1.98 (95%CI: 1.17 to 3.35. However the certainty of the evidence was low to moderate.

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Oral examination for detecting oral cancer

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This review of the diagnostic accuracy of visual inspection compared with biopsy (gold standard) for the diagnosis or oral cancer and oral potentially malignant dissorders included 18 studies. For malignant lesions the pooled sensitivity was 88% (95%CI; 73% to 95%) and specificity 81%(95%CI; 51% to 95%).

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Metastatic lesions in the oral and maxillofacial region

Patients with cancer and comorbid depression have worse anxiety, pain, fatigue, and functioning than do other patients with cancer.

This review of metastatic neoplasms in the oral cavity included 217 observational studies from 33 countries. The 348 cases identified arose from 29 primary sites the most common being lung (21%) and breast (12%).

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Chemotherapy for oral cavity and oropharyngeal cancer

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This review of whether chemotherapy, in addition to radiotherapy and/or surgery for oral cavity and oropharyngeal cancer, results in improved overall survival included 100 studies. the findings indicated some benefit only when used in a few specific circumstances.

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Early detection of oral cancer and oral potentially malignant disorders

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This Cochrane review update of the diagnostic test accuracy of conventional oral examination, vital rinsing, light-based detection, mouth self-examination, remote screening, and biomarkers, used singly or in combination, for the early detection of OPMD or OSCC in apparently healthy adults included 18 studies.

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Oral lichen planus and malignant transformation

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This review of high quality studies of oral lichen planus malignant transformation rate included 10 observational studies. The findings found a higher level of malignant transformation in higher quality studies 2.28% (95%CI; 1.49 to 3.20) compared with reviews including lower quality studies 1.14% (0.84 to 1.49).

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Osteoradionecrosis and tooth extraction before radiotherapy

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This review of the osteoradionecrosis rate in patients with head and neck cancer having toothth extraction performed before radiotherapy included 8 mainly retrospective studies. The pooled incidence rate was estimated at 2.2% (95% CI: 0.6% to 3.9%) although none of the studies controlled for other risk factors.

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