Potentially malignant disorders of the oral cavity: Evaluation guideline

By Aitor III (Own work) [Public domain], via Wikimedia Commons

This new clinical practice guideline from the American Dental Association (ADA) updates the 2010 guideline on “Evidence-based Clinical Recommendations Regarding Screening for Oral Squamous Cell Carcinomas

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Sexual behaviours and oral cancer risk

The treatment effects seemed more pronounced in women, young people and first attempters of suicide.

20 studies reporting 21 data sets were included in this review of the association of sexual behaviours and oral and oropharyngeal cancers. The review suggests that some sexual behaviours increase risk but the quality of the evidence is limited and quantitative estimates of the strength of these associations are not reliable.

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Oral mucositis in cancer patients: no benefit from chlorhexidine mouthwash

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This review of chlorhexidine (CHX) for prevention & treatment of oral mucositis included 12 RCTs with 9 contribution to the meta-analysis. CHX was not significantly effective in preventing mucositis or reducing its severity.

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Top Dental Elf Blogs of 2016

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During 2016 the Dental Elves has published 158 blogs covering a broad range of topics. The most popular blogs of each month are highlighted.

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Oral Mucositis: can honey reduce its severity?

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This review of the use of honey to educe the severity of radio/chemotherapy-induced oral mucositis identified 7 low quality RCTs that suggest that use of honey may reduce the severity of oral mucositis.

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Marijuana use and head and neck cancer risk #CannabisMatters

Cannabis

9 case-controlled studies were included in this review of the effect of marijuana use on head and neck cancer. The findings suggest no association marijuana use and head and neck cancer but other reviews suggest that this may differ by tumour site

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High frequency or prolonged use of mouthwash increased risk of head and neck cancer

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This study from the INHANCE collaboration pooled data from 12 case-controlled studies. Long-term use (35 yrs) of mouthwash was associated with an increase risk OR=1.15 (95%CI; 1.01 to 1.30) of head and neck cancer but with regular (>2 x daily), long-term (>35 years) use OR = 1.75 (95%CI; 1.25 to 2.48).

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Coffee consumption and oral cancer

Prescribing a placebo does not equate to no treatment, because the healthcare setting itself should include all kinds of supportive and therapeutic elements.

This review includes 11 case-controlled and 4 cohort studies and suggests a 37% reduction of oral cancer risk in high coffee drinkers compared with low or no coffee drinkers OR= 0.63 (95%CI; 0.52 – 0.75)

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Tobacco use and alcohol intake key risk factors for head and neck cancer

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The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. This overview paper provides a summary their findings over the past decade.

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Oral cancer- monoclonal antibodies combined with standard treatment may improve outcomes

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12 trials were included in this Cochrane review of molecularly targeted therapies and immunotherapies as adjuncts to standard treatments for oral cancer. Moderate evidence was found that standard therapy plus epidermal growth factor receptor monoclonal antibody (EGFR mAb) reduced mortality and locoregional failures.

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