John Baker reports on Canadian study looking at prescriptions of off-label antidepressants in primary care, which concludes that when antidepressants were used outside of their licence, there was usually not strong evidence supporting the respective indication.
[read the full story...]Antidepressants and psychotherapy for OCD in adults: network meta-analysis
Alan Underwood summarises a recent network meta-analysis of medication and talking treatments for OCD (obsessive-compulsive disorder) in adults.
[read the full story...]Antidepressants: benefits and harms in children and adults
Samei Huda discusses the findings of a recent review into suicidality and aggression during antidepressant treatment. The systematic review and meta-analyses were based on clinical study reports and included some important adverse effects of antidepressants in children and young people.
[read the full story...]No link between SSRI use and violent crime in over 25s
Sarah McDonald considers the implications of a recent cohort study of SSRI use and violent crime, which suffered from the usual headline grabbing media coverage, so typical of research about young people, violence, crime, drugs and mental health.
[read the full story...]Pharmacotherapy for PTSD: an update on the evidence finds some efficacy but small effect sizes
Patrick Kennedy-Williams summarises a recent systematic review of pharmacotherapy for PTSD, which compares antidepressants with placebo for post-traumatic stress disorder. [Please note: this blog was amended on 7/5/15].
[read the full story...]Antidepressant withdrawal syndromes: time to grasp the nettle?
Andrew Shepherd appraises and summarises a systematic review of antidepressant withdrawal symptoms after SSRI discontinuation, which leads him to reconsider his own clinical practice.
[read the full story...]Eating disorders: mapping the (lack of) evidence
Helen Bould summarises a recent review that maps the evidence for the prevention and treatment of eating disorders in young people. Her conclusion? A call to arms for more better quality research to help people affected by these serious illnesses.
[read the full story...]Prenatal SSRI exposure and autism risk: a dilemma for mums-to-be with depression
Amy Green summarises a population-based study of young children which looks at prenatal exposure to SSRI antidepressants and the social responsiveness symptoms of autism.
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