Trying to understand brain networks associated with depression is hampered by how variable the condition is

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At the start of using neuroimaging to try and understand mental health problems, the focus was on a specific area of the brain that might be different.  As the methods have become more sophisticated, the ability to look at how different areas of the brain are linked into functional networks has developed.  Whilst damage to [read the full story…]

Systematic review identifies key parenting factors associated with adolescent depression and anxiety

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Parenting is a tough gig. As a mum of three, I can honestly say that nothing in my everyday professional life comes close to the trials and tribulations of guiding small people through toddlerhood and beyond. Parenting advice comes thick and fast from all corners, most of it unsolicited, some of it anecdotal, much of [read the full story…]

“Everyone’s a winner, all must have prizes!” but which psychotherapy for depression wins, if any?

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Previous meta-analyses in the field of depressive disorders have yielded mixed conclusions about which the most efficacious treatment is.  Within the process of any therapy, there are universal features such as; the therapeutic relationship, rationale for treatment, a patient and therapist belief in treatment, a confidential and respectful space for the patient and so on.  [read the full story…]

Meta-analysis finds that pituitary volume is not affected in people with first episode psychosis or schizophrenia

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* Declaration; I have published articles with two of the authors of this article, including on this topic, and know most of them professionally One influential model of the onset of psychotic disorders such as schizophrenia is the stress-vulnerability model, first put forward by Zubin and Spring in 1977. This model proposes that people at [read the full story…]

Atomoxetine for adult ADHD: the harms outweigh the benefits, according to new systematic review

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Attention Deficit Hyperactivity Disorder (ADHD) is a developmental neurological condition affecting functioning in a number of domains, but in particular, the ability to focus and concentrate, and regulate activity levels.  This is a common disorder with 2.5-4.0% of adults meeting diagnostic criteria for ADHD (Fayyad et al, 2007), and this condition has significant impact on a persons [read the full story…]

Systematic review highlights a lack of evidence about using antidepressants to treat cancer patients with depression

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Having a life threatening disease such as cancer and undergoing gruelling treatment can have detrimental psychological effects. According to a recent review, for instance, the prevalence of depression among cancer patients is 10.8%, when assessed by a standardised clinical assessment (Ng et al. 2011). The authors of this meta-analysis make the argument that established criteria [read the full story…]

Identifying risk factors in first episode psychosis: results from two new meta-analyses

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A first episode of psychosis is a higher risk time for acts of self-harm and of violence, and a chance to engage people, modify risk factors and change outcomes. Two related meta-analyses by Large, Neilssen and Challis are presented in a letter in the Australian and New Zealand Journal of Psychiatry.  They summarise two studies [read the full story…]

Cochrane review finds ‘solid’ evidence for CBT for anxiety in young people, but lacks evidence for long-term benefits

Anxiety disorders, such as generalised anxiety disorder (GAD), social anxiety, panic disorder and phobias, are common and affect between 5 – 19% of all children and adolescents (Costello, 2004; as cited in James et al, 2013, pg. 6).  Anxiety problems in childhood or adolescence can disrupt social and educational life, and may persist into adulthood. [read the full story…]

Cutting across diagnostic categories: Does stimulant medication improve ADHD symptoms in children with autism spectrum disorder?

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Until fairly recently, it was thought that autism spectrum disorder (ASD; previously known as PDD or pervasive developmental disorder) and attention deficit hyperactivity disorder (ADHD) were two entirely separate childhood-onset conditions and that they could not both be diagnosed in one individual. Numerous studies in the last decade have shown that, in reality, a number of [read the full story…]

Do antipsychotics cause progressive brain changes in schizophrenia?

People with schizophrenia taking antipsychotics saw a reduction in grey matter

For over 30 years researchers have found that people with a diagnosis of schizophrenia have, on average, differences on brain scans compared to people without.  Not everybody with a diagnosis of schizophrenia will have these differences and it has not yet been possible to use brain scanning as a test to work out whether someone [read the full story…]