MicroRNAs for diagnosis of squamous cell carcinoma

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Manas Dave looks at a review of the diagnostic accuracy of blood and salivary microRNAs (miRNAs) in discriminating oral squamous cell carcinoma. The review included 20 cross-sectional studies and suggested moderate diagnostic accuracy and higlights a potential are for larger scale studies.

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Sugar free gum and streptococcus mutans levels

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This review of the impact of sugar-free gum (SFG) on the level of oral micro-organisms, specifically Streptococcus mutans included 13 studies 11 of whihc were RCTs. The findings indicated that SFG reduces the load of Streptococcus mutans in the oral cavity compared to controls but noe of teh included studies were at low risk of bias.

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Traumatic dental injuries in primary teeth

Can the physically active, playful environments of pre-school settings provide a blueprint for obesity prevention in primary schools?

This review of the prevalence of traumatic dental injuries (TDI) in primary teeth and factos associated with TDI includes 21 cross-sectional studies.

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Chronic periodontitis: Efficacy of adjunctive antimicrobials

Many drugs are licensed for use in Generalised Anxiety Disorder (GAD), but it is unclear what works best.

This review of the efficacy of antimicrobials adjunctive to scaling and root planing (SRP) in the treatment of chronic periodontitis. 21 RCTs were included with the findings showing that amoxicillin and metronidazole had the largest statistical benefit. Whether this benefit is a clinically important benefit is a wider question.

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Orofacial trauma in wheeled non-motorsports

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This review of the prevalence of orofacial trauma in wheeled non-motor sports athletes included 5 cross-sectional studies involving 132,132 participants. Analyses showed the overall prevalence of orofacial trauma = 21.7% (95%CI; 8.7 to 34.7%) however the evidence was of very low certainty.

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Caries detection methods: How accurate are they?

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This review of the accuracy of different methods for detecting carious lesions in primary and permanent teeth compares visual inspection, radiographs and fluorescence-based detection. 240 studies were included and the findings suggest that visual inspection was adequate for most patients.

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Alveolar ridge preservation techniques

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16 RCTs were included in this Cochrane review update of the effectiveness of techniques for alveolar ridge preservation (ARP) following dental extractions prior to implant placement. The findings suggest that ARP techniques may minimise the overall changes in residual ridge height and width six months after extraction, but the evidence is very uncertain

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Diabetes and dental implants

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This review of the possible association between diabetes mellitus and dental implant complications included 10 cohort studies (8 prospective 2 retrospective). The findings suggest that patients with diabetes are more likely to have clinical complications with dental implants.

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Dentigerous cysts and tooth eruption

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This review of factors influencing eruption of teeth associated with dentigerous cysts only included 4 small single-centre retrospective studies providing very low certainty evidence.

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Osteoradionecrosis incidence and the timing of dental extractions

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This review of whether the incidence of osteoradionecrosis differed between patients who have dental extractions before or after radiotherapy (RT) included 24 studies (19 retrospective 5 prospective). While the findings suggest that the incidence is similar if extractions are undertaken before or after RT the quality of the evidence is limited.

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