In this blog we look at a review of the malignant transformation rate (MTR) for oral submucous fibrosis (OSF). The review included 16 studies estimating the malignant transformation rate as 6% (95%CI: 2% to 10%)[read the full story...]
Salivary lactate dehydrogenase in oral and potential malignant disorders
In her first Dental Elf blog Iris Vaid looks at a review of salivary lactate dehydrogenase (LDH) as a potential diagnostic marker for oral cancer and oral potentially malignant disorders.[read the full story...]
Oral examination for detecting oral cancer
This review of the diagnostic accuracy of visual inspection compared with biopsy (gold standard) for the diagnosis or oral cancer and oral potentially malignant dissorders included 18 studies. For malignant lesions the pooled sensitivity was 88% (95%CI; 73% to 95%) and specificity 81%(95%CI; 51% to 95%).[read the full story...]
Human Papilloma Virus in oral potentially malignant disorders
In this blog Manás Dave looks at a review of the prevalence of human papilloma virus (HPV) in oral potentially malignant disorders (OPMD). Although 52 studies were included one in five OPMDs being HPV positive is not a substantial link so teh findings need to be interpreted cautiously.[read the full story...]
Oral submucous fibrosis: Is treatment with hyaluronidase and corticosteroids effective?
This review of the efficacy of hyaluronidase combined with corticosteroids in the management of oral submucous fibrosis (OSF)included 6 small RCTs of short duration. Only one of the RCTs was considered to be at low risk of bias so additional well conducted and reported studies with larger sample are needed to evaluate treatments for OSF.[read the full story...]
Curcumin for management of oral submucous fibrosis
This review evaluating the evidence on the effectiveness of curcumin in the management of oral submucous fibrosis included 6 small RCTs providing inconclusive evidence of a potential benefit.[read the full story...]
Aloe vera for treatment of oral submucous fibrosis?
This review effectiveness of aloe vera on alleviating the symptoms of oral submucous fibrosis included 6 RCTs . The findings suggest a possible benefit but 5 of the trials were at high risk of bias so the findings should be viewed cautiously.[read the full story...]
Oral potentially malignant disorders – how common are they?
This review of the prevalence of oral potentially malignant disorders included 22 observational studies providing a pooled estimate for prevalence of 4.47% (95% CI;2.43-7.08).[read the full story...]
Oral potentially malignant disorders and impact on quality of life
14 studies were included in this review of the impact of oral potentially malignant disorders of the quality of life. However, they were mainly focused on oral lichen planus, so they provide little evidence for the impact of the wide range of OPMDs on the quality of life.[read the full story...]
Small trial suggests a potential benefit for combination of triamcinolone acetonide and salvianolic acid B for Oral submucous fibrosis patients
Oral submucous fibrosis (OSF) is characterized by chronic inflammation and progressive subepithelial connective tissue fibrosis. This can involve the oral cavity, pharynx and upper third of the oesphagus. It is more commonly found in patients in the Asian subcontinent and the Far East. The aetiology is considered to be multi-factorial with areca nut chewing, nutritional [read the full story…]