This review of the efficacy and safety of topical interventions used for recurrent aphthous stomatitis included 72 studies assessing 29 different interventions. Most of the interventions did not demonstrate significant differences with limitednumbers of studies for some interventions and overal limitations in the quality of the evidence.
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This review of the effect of probiotics on gingival inflammation and oral microbiota in patients suffering from plaque-induced gingivitis included 11 RCTs. No clear evidence was found to indicate that oral probiotics have a positive effect on gingival inflammation and oral microecological environment of patients with gingivitis.
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Kathrin Cohen Kadosh appraises a recent systematic review relating to her own Wellcome Trust funded research on better gut microbiome and how increasing levels of probiotics and prebiotics may help prevent and treat anxiety in young people.
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This review of the the efficacy of probiotics on oral Candida spp. includes 12 RCTs and suggests a possible benefit. However the quality of the evidence is limited so the findings should be intepreted cautiously.
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This review of the the efficacy of probiotics in the treatment of gingivitis included 10 small short term studies providing limited weak evidence for any effect on gingivitis.
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This review of the effect of probiotic containing dairy products on oral health included 32 studies involving a broad range of dairy products suggesting a positive effect on S.Mutans (SM) levels and salivary pH.
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A team from the Centre for Affective Disorders at King’s College London appraise a new systematic review on probiotics for depression, which claims to have found robust and compelling evidence that these supplements can alleviate depressive symptoms.
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4 small RCTs of probiotics as an adjunct to scaling and root planing for management of chronic periodontitis were identified for this review. While a statistical significant benefit was demonstrated the limited number of small studies means that these findings should be interpreted with caution.
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This review of probiotics use for caries and periodontal disease management identified 50 studies. Most focused on surrogate outcomes (bacterial counts) and the overall quality of the evidence supporting probiotic therapy was graded as very low for all outcomes.
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This small trial of probiotics as an adjunct to toothbrushing with a fluoride toothpaste to reduce caries in pre-school children suggests some additional benefit. Further studies are needed to clarify the findings, assess dose response, acceptability and cost effectiveness.
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