psychosis

Psychosis is a condition that affects a person’s mind and causes changes to the way that they think, feel and behave. A person who experiences psychosis may be unable to distinguish between reality and their imagination. People who are experiencing psychosis are sometimes referred to as psychotic. They may have hallucinations (where you see or hear things that are not there) and/or delusions (where you believe things that are untrue).

Our psychosis Blogs

Clozapine and infection risk: new evidence from Hong Kong’s 20-year cohort study

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Clozapine is described as the gold standard treatment for schizophrenia but a new cohort study suggests it is associated with an increased risk of infections, particularly in older patients, further solidifying the case for holistic care.

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Spotting the storm before it breaks: mapping the prodrome of severe mental illness

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People with severe mental illness often face years of poor health before diagnosis. A new study uses machine learning and clinical notes to map the early warning networks of symptoms that could help us intervene earlier.

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Widening the lens on delusions: a global meta-analysis shows our scales miss many common themes

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This big meta-analysis pooled 155 studies from 37 countries and found many more delusional themes than standard assessment tools capture. Clinicians should watch for “non-classical” content, and researchers should widen how we measure delusions.

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Core beliefs in psychosis: new insights from a systematic review

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Negative core beliefs like “I’m worthless” or “people can’t be trusted” are linked to hallucinations, paranoia, and suicidality. This new systematic review shows how deep-rooted schemas shape psychosis, and what this means for psychological therapies.

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Talking about suicide in psychosis: does a targeted therapy make a difference?

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People with psychosis face unique risks around suicide, but most treatments aren’t designed with them in mind. This new RCT tested a targeted therapy that tackles those specific challenges. So what did it find?

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The scars that shape the mind: childhood adversity and the risk of psychosis

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Emotional abuse in childhood was linked to a more than 3.5x greater chance of developing psychosis later in life. This comprehensive new meta-analysis explores the role of early trauma, sex differences, and symptom onset timing in psychosis risk.

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Psychosis stigma in the Middle East: shining a light on hidden struggles

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Shuichi Suetani and Jon Paul Teo consider a new systematic review, which highlights the significant stigma faced by people with psychosis and their families in Middle Eastern communities, and suggests culturally sensitive ways forward.

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Cannabis, psychosis and the structural realities for ethnic minorities

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KCL MSc student Geetika Sharma reviews a study that looks at the contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe.

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What’s in the blood? Immune cell changes in schizophrenia

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Dr Fabiana Corsi-Zuelli discusses the differences in immune cell counts in patients with schizophrenia compared to controls; highlighting a recent meta-analysis by Dudeck et al. (2025) that reinforces the growing consensus that immune dysfunction plays a role in schizophrenia.

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Psychosis and loneliness: two struggles, one endless loop

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A group of UCL MSc students reflect on a qualitative review looking at the experience of loneliness among people with psychosis, which makes actionable clinical suggestions to enhance connection and address isolation.

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