Dementia in Down syndrome: Are we ready for a clinical trial?

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Leen Vereenooghe summarises the TOP-COG study (Towards Onset Prevention of COGnitive decline in adults with Down syndrome). This pilot RCT highlights the need to educate people with learning disabilities and their carers about the importance of research participation.

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Permanent tooth agenesis in Down syndrome

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This review included 13 observational studies involving 1080 patients demonstrating high prevalence and severity of tooth agenesis in Down syndrome individuals.

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Impacts of special care unit for older adults with learning disabilities and dementia evaluated over three years

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People with learning disability may be more likely to develop dementia than other people.

Here Ros Hithersay looks at the findings of a three year evaluation of a special care unit for people with dementia.

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People with Down syndrome experience higher incidence of depression than other people with learning disabilities according to findings of systematic review

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People with learning disabilities have an increased risk of experiencing mental health problems but we need to understand more about the prevalence and presentation of these issues to help clinicians offering appropriate and effective treatments.

Here Angela Henderson looks at a systematic review of the literature on uni-polar depression in people with Down syndrome.

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Trajectory of dementia: is it different for people with Down syndrome?

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Down syndrome is the most common cause of learning disability in the UK and increased risk of developing Alzheimer’s dementia is well documented.

In her debut blog, Silvana Mengoni looks at a paper which uses three case studies to consider some interesting trajectories of dementia which raise some interesting questions.

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Managing the care of adults with Down syndrome

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Down syndrome is the most common cause of learning disability in the UK and life expectancy has shown a dramatic increase in the last fifty years. However, people with Down syndrome face significant health issues.

In this blog, GP Matt Hoghton looks at a recent clinical review published in the BMJ, which provides advice and guidance on managing care and support for people with Down syndrome.

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Visual deficits in adults with Down syndrome explored

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Research by SeeAbility and the RNIB suggests that adults with learning disabilities are ten times more likely to be blind or partially sighted than the rest of the population. If they have severe or profound learning disabilities, then they are likely to have serious sight problems. There already exists some guidance for GPs on responding [read the full story…]

Comparison of chlorhexidine application methods on dental health of people with Down syndrome

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Periodontal disease refers to issues relating to or affecting the tissues surrounding the neck and root of a tooth, It is a significant oral health problem for people with Down syndrome. It can be a cause of tooth loss and has a number of contributing factors, which includes poor oral hygiene. Antimicrobial agents like chlorhexidine [read the full story…]

New research begins to focus on therapeutic interventions on the underlying cause of learning disabilities

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With the background of 11% of total United States government spending for disability support in 2006, the authors from Boston Children’s Hospital and Harvard Medical School highlight the financial and social imperatives to improve services for people with learning disabilities. They remind us that most of the current focus on research has been on environmental [read the full story…]