Guy Goodwin reviews a new paper in the Lancet Psychiatry by Jauhar, McKenna and Laws, that calls into question the trustworthiness of the NICE bipolar disorder guidance.
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Ioana Cristea considers the possible causes responsible for the apparent narrowing of the drug-placebo gap, which over the last 30 years has seen estimates of depression symptom reduction from antidepressants fall from 70% to 30%.
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Dan-Mikael Ellingsen explores the neurochemistry of placebo effects in major depression, as he reviews a recent study of the association between placebo-activated neural systems and antidepressant responses.
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David Steele summarises a review of systematic reviews and meta-analyses, which looks at the mediators and moderators of the placebo effect in psychiatry.
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Patrick Kennedy-Williams summarises a recent systematic review of pharmacotherapy for PTSD, which compares antidepressants with placebo for post-traumatic stress disorder. [Please note: this blog was amended on 7/5/15].
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In her debut blog, Nicola Coop summarises a recent meta-analysis looking at the use of antidepressants, antipsychotics and hormonal therapy for people with anorexia nervosa.
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Joe Judge reviews a recent meta-analysis of placebos in antipsychotic trials, which finds that the placebo response has increased significantly in the last 50 years.
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Joe Judge revels in a new network meta-analysis looking at placebo for depression published in BMC Medicine, which has been supplemented by a series of commentaries and blogs. Thought-provoking stuff!
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