Sjögren’s syndrome: treatments for dry mouth and hyposalivation

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36 studies were included in this review of treatment options for xerostomia, hyposalivation and quality of life in patients with Sjögren’s syndrome provinding evidence to support pilocarpine use. However the number of studies were limited and adverse effects were common.

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Insufficient evidence for effects of non-pharmacological interventions for the relief of dry mouth

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It has been estimated that between 10-26% of men and 10-33% of women experience dry mouth. The subjective sensation of dry mouth is called xerostomia and can be found in people with normal salivary gland function. The normal range of salivary production ranges from 0.5 to 1.5 litres per day.  The aim of this Cochrane [read the full story…]

Minor salivary gland biopsy in the diagnosis of Sjögren's syndrome

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Sjögren’s syndrome (SS) is one potential cause of dry mouth.  It is thought to affect 0.5-1% of the population and is more common in females (M/F ratio 1:9).  SS is an autoimmune disease characterised by chronic T- and B-cell infiltration of the salivary glands or lachrymal glands that results in gland dysfunction.   SS has a [read the full story…]