Identifying risk factors in first episode psychosis: results from two new meta-analyses

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A first episode of psychosis is a higher risk time for acts of self-harm and of violence, and a chance to engage people, modify risk factors and change outcomes. Two related meta-analyses by Large, Neilssen and Challis are presented in a letter in the Australian and New Zealand Journal of Psychiatry.  They summarise two studies [read the full story…]

Review suggests that radiotherapy was associated with higher rates of implant loss

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Implant–supported restorations show good success rates in healthy tissues while studies in irradiated jaws contrasting outcomes have been reported. The aim of this review was 
to assess the survival rate of titanium implants placed in irradiated jaws. The Medline, Embase, and CENTRAL, and  OpenGRAY databases were searched together with a number of journals (Clinical Implant [read the full story…]

Common antidepressants associated with increased risk of postpartum haemorrhage

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Postpartum haemorrhages are serious birth complications that represent one of the leading causes of maternal mortality and morbidity. While incidences of postpartum haemorrhages have risen steadily in the past decades (in the US alone, numbers increased from 2.3% to 2.9% from 1994 to 2006), there is little evidence as to why. Antidepressants – especially selective [read the full story…]

Study shows that tooth wear was present in around 30% of young European adults

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There is increasing interest in the levels of tooth wear being seen with a recent systematic review suggesting that between 10-30% of children have signs of established wear ( Dental Elf Sept 2011) .  The aim of this study was to determine prevalence of tooth wear on the oral and facial surfaces in 18– 35 year [read the full story…]

It’s not the combat, maybe it’s the drinking in vulnerable young men

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A cohort study published in JAMA tried to answer the question what are the risk factors for suicide in the US military. This is a hot topic as the rate of suicide has increased in US military personnel from about 11/100,000 people in 2005 to about 18/100,000 so that now deaths from suicide outnumber deaths [read the full story…]

Tricyclic antidepressants are associated with higher risk of bone fracture

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While most people would likely associate tricyclic antidepressants (TCAs) with more common adverse effects such as dry mouth, sedation and constipation, there is some evidence to suggest increased occurrence of bone fractures (Vestergaard, Rejnmark, & Mosekilde, 2006). However, the topic remains controversial and conflicting results about the association of TCAs and fracture risk abound (e.g. [read the full story…]

ADHD in childhood is not linked to later development of bipolar disorder

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Bipolar disorder is considered a hereditary condition. There is emerging evidence that prodromes/early symptoms are evident in children before disorders develop. This potentially offers a chance to treat and prevent the development of mental health problems in adulthood. Being able to identifying early symptoms of the onset of this mental health disorder is clearly important, however, [read the full story…]

Maternal antidepressant use in pregnancy may be associated with a small increased risk of autism

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The prevalence of autistic spectrum disorders has risen dramatically in the last thirty years, with recent estimates suggesting that 1 in 88 children in the United States have an autistic spectrum disorder. This increasing prevalence could simply be due to changes in the diagnosis of such disorders and so be of little interest. However, there [read the full story…]

Limited evidence available of the caries risk in children and adolescents with cystic fibrosis

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Cystic fibrosis (CF) is a genetic disorder that leads to the overproduction and accumulation of mucus in the lungs, which can result in airway obstruction and life-threatening bacterial.   Four risk factors related to CF are considered to increase the risk of dental caries; a 20- fold increase in intraoral Streptococcus mutans levels; gastroesophageal reflux disease [read the full story…]

Foetal exposure to sodium valproate is linked with autism risk

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The risks of congenital malformations and impact of cognitive development after foetal exposure to anti-epileptic drugs has been known for some time. Sodium valproate is a frequently used drug for epilepsy and other disorders (including bipolar disorder and migraine). The researchers aimed to examine the link between foetal exposure and subsequent development of autism. Methods [read the full story…]