Inferior alveolar nerve block: can NSAIDs improve anaesthetic success?

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This review of the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) as premedication on the success of inferior alveolar nerve block includes 13 RCTs suggesting NSAIDs have a positive impact on success.

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Prednisolone for post-endodontic pain?

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This randomised controlled trial of a single, preoperative oral dose of prednisolone on post-endodontic pain involved 400 patients demonstrating a significant reduction in pain at 6,12 and 24 hours.

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Pre-operative analgesia for patients with pulpitis improved anaesthetic success

This RCT does not establish equivalence between mindfulness-based cognitive therapy and antidepressants for recurrent depression.

16 RCTs involving 1900 patients were included in this review of pre-op analgesia for patients with pulpitis . The findings suggest that premedication with analgesics improves the success rate of local anaesthesia.

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Endodontic postoperative pain: which non-steroidal anti-inflammatory drug?

This RCT does not establish equivalence between mindfulness-based cognitive therapy and antidepressants for recurrent depression.

The review of NSAIDs for endodontic postoperative pain suggests that NSAIDs are effective. A combination of ibuprofen 600 mg and acetaminophen 1000 mg and Ibuprofen 600 mg were both effective. More studies are need to assess teh most effective NSAIDs dosages and does intervals.

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Oral leukoplakia: very limited evidence for treatments

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The aim of this Cochrane review was to assess the effectiveness, safety and acceptability of treatments for oral leukoplakia in preventing oral cancer.

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Few adverse events with single dose oral analgesics for acute postoperative pain

This overview of adverse event rates associated with single dose oral analgesics includes data from 39 Cochrane reviews, and provides evidence that adverse events rates are generally similar with active drug and placebo.

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Anti-inflammatory drugs for depression: new review points to benefits, but more research needed

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Helge Hasselmann highlights a recent systematic review of anti-inflammatory drugs for depression, which concludes that NSAIDs, in particular celecoxib, decreases depressive symptoms without increased risk of adverse effects. However, the meta-analysis has a number of draw-backs, which make the study findings far from convincing.

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Non-steroidal anti-inflammatory drugs may help reduce schizophrenia symptoms

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There is an increasing body of research that suggests that inflammation plays an important role in the development of schizophrenia. It is therefore logical to consider using anti-inflammatory drugs as a component within the overall treatment approach for people with schizophrenia. This new systematic review and meta-analysis carried out by researchers from the University Medical [read the full story…]