New systematic review protocols for periodontal disease and caries prevention

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Two new systematic review protocols have been published in the Cochrane Library recently.  This indicates research in progress, of course, and we would not expect results to be published for some time.  However, people who are investigating these topic areas may like to know that a review is under way. The full text of each [read the full story…]

Preoperative antibiotics may decrease dental implant failure

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The aim of this review was to assess whether patients undergoing dental implants who receive peri-operative antibiotics have lower failure rather than those not who do not receive antibiotics. The authors searched medline  for studies in English with test and control groups . Antibiotic use was classified as a single preoperative dose, a single preoperative [read the full story…]

Maxillomandibular advancement surgery may be an effective treatment for patients with obstructive sleep apnoea

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This  is a critical summary  prepared by ADA Centre for Evidence-Based Dentistry  of a systematic review originally published  in 2010. The original review looked at which surgical modifications of the upper airway were most effective  in reducing the apnoea-hypopnoea index (AHI) for patietns suffering with obstructive sleep apnoea (OSA). OSA is relatively common occurring in [read the full story…]

Oral glucosamine sulphate not superior to placebo in treating osteoarthritis in temporomandibular joint

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Osteoarthritis (OA)  of the temporomandibular joint is found in about 5-16% of those referred with temporomandibular disorders (TMD).  The aim of this study was to evaluate the effect of oral glucosamine sulphate, compared with placebo, on pain and function in patients diagnosed with osteoarthritis in the temporomandibular joints. Patients with the research diagnostic criteria for [read the full story…]

Updated systematic review on surgery for oral cancer

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The existing Cochrane systematic review on surgical treatment of oral and oropharyngeal cancers has been updated, with important changes to the conclusions. The reviewers concluded that  there was weak evidence to suggest that dissection of clinically negative neck nodes at the time of removal of the primary tumour reduced cancer recurrence.  However, there was insufficient [read the full story…]

The evidence remains weak for aripripazole as a treatment for schizophrenia

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First generation typical antipsychotics (e.g. chlorpromazine and haloperidol) have historically been used a great deal to treat people with schizophrenia. More recently, second-generation atypical antipsychotics (e.g. risperidone and olanzapine) have been more frequently used. For many, these drug therapies help to reduce psychotic episodes and the overall impact of the illness, but not all patients [read the full story…]

Using ice chips reduces oral mucositis in patients undergoing chemotherapy

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Cancer treatment is increasingly effective but is associated with short and long term side effects. Oral side effects remain a major source of illness despite the use of a variety of agents to prevent them. One of these side effects is oral mucositis (mouth ulcers). The aim of this study was to assess the effect [read the full story…]

Benzodiazepines may protect against seizures in alcohol withdrawal syndrome

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Every once in a while the Cochrane library publish an overview of reviews to summarise the evidence for a specific intervention. Such an overview has recently been made available to bring together all of the Cochrane reviews that assess the effectiveness and safety of pharmacological interventions in the treatment of alcohol withdrawal. The overview brings [read the full story…]

Very low quality evidence for the efficacy of most neurosurgical procedures for trigeminal neuralgia

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The trigeminal nerve is the fifth cranial nerve and one of the largest in the head. It provides sensation to the face and  is called trigeminal because it splits into three main branches. When neuralgia (nerve pain) occurs in the trigeminal nerve it causes severe and sudden face pain. It has an incidence rate of [read the full story…]

Insufficient evidence for timing of implant placement following extraction

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This systematic review publication based on a Cochrane review was first published in 2010 . The American Dental Association Centre for Evidence-based Dentistry has now published a critical summary of this review. The review was of high quality, only considering randomised controlled trials comparing  immediate (I), immediate-delayed (ID) or delayed (D) implant placement.  However most [read the full story…]