This Cochrane review of cytokines and growth factors for preventing oral mucositis in patients having cancer treatment included 35 RCTs finding keratinocyte growth factor beneficial in the prevention of oral mucositis .
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This Cochrane review of drugs for the prevention of radiation-induced salivary gland dysfunction included 39 studies, while a range of agents was tested the evidence found is not sufficient to highlight much promise in terms of effective preventative treatments.
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This review of chlorhexidine (CHX) for prevention & treatment of oral mucositis included 12 RCTs with 9 contribution to the meta-analysis. CHX was not significantly effective in preventing mucositis or reducing its severity.
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This review of the use of honey to educe the severity of radio/chemotherapy-induced oral mucositis identified 7 low quality RCTs that suggest that use of honey may reduce the severity of oral mucositis.
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Claire Niedzwiedz examines a recent systematic review which looks at the possible harm caused by the 2008 financial crisis and recession on the health of people living across Europe.
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40 studies were identified for this review of dental implants in irradiated patients. While survival rates were good, they were lower than in non-irradiated areas. As the majority of the included studies were retrospective the findings should be viewed cautiously.
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9 case-controlled studies were included in this review of the effect of marijuana use on head and neck cancer. The findings suggest no association marijuana use and head and neck cancer but other reviews suggest that this may differ by tumour site
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This review of smoking cessation for patients with head and neck cancer included 8 studies ( 3 RCTs) and suggests that those receiving counseling had a 26% higher quit rate than with controls
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This study from the INHANCE collaboration pooled data from 12 case-controlled studies. Long-term use (35 yrs) of mouthwash was associated with an increase risk OR=1.15 (95%CI; 1.01 to 1.30) of head and neck cancer but with regular (>2 x daily), long-term (>35 years) use OR = 1.75 (95%CI; 1.25 to 2.48).
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This review includes 11 case-controlled and 4 cohort studies and suggests a 37% reduction of oral cancer risk in high coffee drinkers compared with low or no coffee drinkers OR= 0.63 (95%CI; 0.52 – 0.75)
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