This review of the prevalence of autoimmune disorders in patients with oral lichen planus (OLP) and their magnitude of association included 153 studies. while links between autoimmune thyroid diseases and diabetes mellitus where shown a majority of the included studies were of low quality.
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This review of high quality studies of oral lichen planus malignant transformation rate included 10 observational studies. The findings found a higher level of malignant transformation in higher quality studies 2.28% (95%CI; 1.49 to 3.20) compared with reviews including lower quality studies 1.14% (0.84 to 1.49).
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This review of effect of microwave disinfection on the dimensional stability of denture base acrylic resins included 7 in-vitro studies. A wide range of microwave disinfection protocols were used with the reviewers specifying two protocols that may be safe. However because of the heterogeneity and the small number of studies included these finding should be considered cautiously.
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This review of the the frequency of osteonecrosis of the jaw in bisphosphonate users undergoing dental interventions included 27 studies. having dental procedures of 2.7% (95%CI: 0.9 to 5.2%) being higher in those having dental extractions 4.1% (95%CI: 1.5 to 7.7%).
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Conventional ice chip cryotherapy was compared with a novel intraoral cooling device in this multi-centre randomised controlled trail conducted in five Scandinavian centres.
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This review of the efficacy of topical hyaluronic acid (HA) for reducing the signs and symptoms of recurrent aphthous stomatitis (RAS) included 9 studies 8 of which were RCTs. The findings suggest that HA may be a potential treatment option for RAS but the evidence is of very low certainty.
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This review of the effectiveness of topical anaesthesia in in reducing pain during local anaesthetic injections for dental procedures included 22 RCTs. Statistically significant differences were seen during needle puncture with topical anaesthetic use in the maxilla and palate but not the mandible.
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This review comparing topical natural substances with conventional antifungals in the treatment of denture stomatitis included 17 studies 14 of which were RCTs. A wider range of natural products were tested and showed similar efficacy to antifungals however, almost all the studies were at high risk of bias so the certainty of the evidence is very low.
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Manas Dave takes a look at this systematic review of the efficacy of dexamethasone in the treatment of oral lichen planus (OLP).
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This review of the use and diagnostic accuracy of saliva tests for the detection of SARS-CoV-2 included 16 studies. THe findings suggests good diagnostic accuracy but furteher research is needed to determine confounding factors such as method and time of sample collection, transport medium, storage etc. prior to population testing.
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