Candida albicans: higher prevalence in children with early childhood caries

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This review of a possible association between oral Candida albicans and early childhood caries (ECC) included 15 cross-sectional studies.The prevalence of C. albicans in children with ECC was found to be significantly higher than in caries-free children.

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Salivary biomarkers for diagnosing periodontal disease

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This review of salivary biomarkers for diagnosing periodontal disease only identified 4 studies at high risk of bias but suggests a small number of potential biomarkers. However the findings should be interpreted with caution.

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Chronic periodontitis is associated with a characteristic bacterial profile of saliva

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Periodontal disease is common and here in the UK 10-15% of adults have chronic periodontal disease.  It is a multifactorial disease and subgingival bacteria play an important role in the pathogenesis of the disease. The aim of this study was to see if chronic periodontitis is associated with a characteristic bacterial saliva profile, and if [read the full story…]

Insufficient evidence for effects of non-pharmacological interventions for the relief of dry mouth

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It has been estimated that between 10-26% of men and 10-33% of women experience dry mouth. The subjective sensation of dry mouth is called xerostomia and can be found in people with normal salivary gland function. The normal range of salivary production ranges from 0.5 to 1.5 litres per day.  The aim of this Cochrane [read the full story…]

Review finds no robust evidence of a relationship between salivary proteins and dental caries

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There is increasing interest in the use of salivary proteins as biomarkers for oral diagnostics and some studies have suggested potential for  these biomarkers in  oral cancer and Sjögrens syndrome . The aim of this review was to evaluate the potential of salivary proteins as biomarkers for dental caries An electronic search was performed in [read the full story…]

Evidence for the efficacy of clinical methods to assess dry mouth is sparse

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Salivary is a complex substance than contains electrolytes, mucus, glycoproteins, enzymes, lysosomes and immunoglobulin. Its normal production is considered important for oral health.  The aim of this review was to evaluate the quality of the evidence for the efficacy of diagnostic methods used to identify oral dryness. The authors searched the PubMed, Cochrane Library and [read the full story…]

Some evidence for the presence of hepatitis viruses A, B and C in oral fluids

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Viral hepatitis is caused by five distinct viruses (A-F) and they represent a significant worldwide healthcare problem. Three of the viruses hepatitis A, B and C (HAV, HBV, HCV) are the most common causes. Recently, there has been renewed interest in whether oral fluids can be considered as a source of viral hepatitis transmission.  There [read the full story…]