Oral lichen planus: Rate of malignant transformation

Lichen_planusWickham's

This review of the malignant transformation rate (TR) of oral lichen planus included 21 observational studies the majority of which were retrospective. The overall estimate of TR was 1.4%.

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Oral potentially malignant disorders – how common are they?

Leukoplakia02-04-06

This review of the prevalence of oral potentially malignant disorders included 22 observational studies providing a pooled estimate for prevalence of 4.47% (95% CI;2.43-7.08).

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Photodynamic therapy for oral lichen planus?

iStock_000001604217XSmall dental laser

This review of photodynamic therapy (PDT) for management of symptomatic of oral lichen planus included 5 small studies of limited quality that suggest PDT may be beneficial.

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Hepatitis C and oral lichen planus

HCV

This review of the association between hepatitis C virus (HCV) and oral lichen planus (OLP) identified 19 case-controlled studies. While a 6-fold increase in risk of HCV infection was noted in OLP patients a majority of the studies took place in areas with high endemic HCV rates and there is some concern regarding publication bias and the quality of the available studies.

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Laser therapy for oral lichen planus

Lichen_planusWickham's

This review comparing low level laser therapy (LLLT) with steroids for the treatment of oral lichen planus only identified 5 studies none of which were at low risk of bias. Further high quality trials are needed to assess the efficacy of LLLT.

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Study finds better oral hygiene improved oral lichen planus

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This small randomised trial found improvements in quality of life for patients with oral lichen planus at both 4 weeks and 20 weeks following implementation of a structured oral hygiene instruction.

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Oral lichen planus: is topical tacrolimus better than clobetasol?

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Ten small RCTs were included in this review. They suggest that topical tacrolimus is more efficacious than clobetasol for oral lichen planus.

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Oral potentially malignant disorders and impact on quality of life

leukoplakia

14 studies were included in this review of the impact of oral potentially malignant disorders of the quality of life. However, they were mainly focused on oral lichen planus, so they provide little evidence for the impact of the wide range of OPMDs on the quality of life.

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Small study suggests that low-level laser therapy may have some benefit in treatment oral lichen planus

oral_lichen

Oral Lichen Planus (OLP) is a common chronic immunological disease the treatment of which remains a challenge for clinicians.  Two Cochrane reviews  have recently been published regarding the treatment of OLP (Chang et al 2012 and Thongorasom et al 2011 ). The quality of evidence for treatments for OLP is weak, but topical steroids are [read the full story…]

Malignant transformation in patients with oral lichen planus

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This cohort study of 327 oral lichen planus (OLP) patients; 229 women (70.0%) and 98 men (30.0%), was conducted using data from a cohort of caucasian patients from Italy with clinical and pathologic diagnosis of OLP, according to revised and modified World Health Organization diagnostic criteria. Follow-up of the patient cohort was started 6 months [read the full story…]