This review of the diagnostic accuracy of visual inspection compared with biopsy (gold standard) for the diagnosis or oral cancer and oral potentially malignant dissorders included 18 studies. For malignant lesions the pooled sensitivity was 88% (95%CI; 73% to 95%) and specificity 81%(95%CI; 51% to 95%).
[read the full story...]
This update of an earlier review of the malignant transformation rate of oral leukoplakia included 24 retrospective studies. The pooled proportion of malignant transformation was 9.8% (95%CI; 7.9 to 11.7%)
[read the full story...]
Marianne Dobson in her first blog for the Dental Elf takes a look at a systematic review looking at the main clinical features of proliferative verrucous leukoplakia
[read the full story...]
This review of the rate of malignant transformation of oral leukoplakia included 34 many retrospective observational studies. The estimated mean malignant transformation rate was 9.7% (95%CI; 7.8% to 11.7%).
[read the full story...]
This review of the association between toombak use and oral leukoplakia and oral squamous cell carcinoma included 8 observational studies suggesting a strong association.
[read the full story...]
This review of the prevalence of oral potentially malignant disorders included 22 observational studies providing a pooled estimate for prevalence of 4.47% (95% CI;2.43-7.08).
[read the full story...]
The aim of this Cochrane review was to assess the effectiveness, safety and acceptability of treatments for oral leukoplakia in preventing oral cancer.
[read the full story...]
14 studies were included in this review of the impact of oral potentially malignant disorders of the quality of life. However, they were mainly focused on oral lichen planus, so they provide little evidence for the impact of the wide range of OPMDs on the quality of life.
[read the full story...]
This review of the malignant transformation rate of oral leukoplakia included 24 studies, the majority of which were retrospective. The range of malignant transformation was between 0.13% and 34.0%. The quality of the available data was limited and there is a need for higher quality well-reported studies.
[read the full story...]
This review of photodynamic therapy (PDT) for oral premalignant lesions only identified a small number of poor quality studies that provide insufficient evidence for the effectiveness of PDT for the management of oral premalignant lesions.
[read the full story...]
