Oral potentially malignant disorders – how common are they?

Leukoplakia02-04-06

This review of the prevalence of oral potentially malignant disorders included 22 observational studies providing a pooled estimate for prevalence of 4.47% (95% CI;2.43-7.08).

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Oral leukoplakia: very limited evidence for treatments

leukoplakia

The aim of this Cochrane review was to assess the effectiveness, safety and acceptability of treatments for oral leukoplakia in preventing oral cancer.

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Oral potentially malignant disorders and impact on quality of life

leukoplakia

14 studies were included in this review of the impact of oral potentially malignant disorders of the quality of life. However, they were mainly focused on oral lichen planus, so they provide little evidence for the impact of the wide range of OPMDs on the quality of life.

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Oral leukoplakia: malignant transformation rate highly variable

herpetic ulcer on tongue

This review of the malignant transformation rate of oral leukoplakia included 24 studies, the majority of which were retrospective. The range of malignant transformation was between 0.13% and 34.0%. The quality of the available data was limited and there is a need for higher quality well-reported studies.

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Photodynamic therapy: review finds insufficient evidence of its effectiveness for oral premalignant lesions

iStock_000001604217XSmall dental laser

This review of photodynamic therapy (PDT) for oral premalignant lesions only identified a small number of poor quality studies that provide insufficient evidence for the effectiveness of PDT for the management of oral premalignant lesions.

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Malignant transformation rates in oral potentially malignant disorders

oral_lichen

The aims of the study were to determine how frequently oral potentially malignant disorders (OPMDs) transform to cancer and to identify clinical and histological factors determining the rates of transformation. The study cohort  included 1357 patients with biopsy-confirmed OPMDs seen at Guy’s Hospital between 1990 and 1999 and followed up until 2005.  The patients’ details [read the full story…]