Oral cancer – adjunctive diagnostic tests

OLYMPUS DIGITAL CAMERA

This Cochrane review update was to estimate the diagnostic accuracy of index tests for the detection of oral cancer and oral potentially malignant disorders, in people presenting with clinically evident suspicious and innocuous lesions.

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Oral leukoplakia and rate of malignant transformation

Leukoplakia

This update of an earlier review of the malignant transformation rate of oral leukoplakia included 24 retrospective studies. The pooled proportion of malignant transformation was 9.8% (95%CI; 7.9 to 11.7%)

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Malignant oral lesions in children and adolescents

Burkitt lymphoma, touch prep, Wright stain

This review of the the prevalence, types and distribution of malignant oral lesions in children and adolescents included 43 retrospective studies reporting on 64,522 biopsies. The findings indicate an overall prevlence of 1.93% (95%CI; 1.21 to 2.80.

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MicroRNAs for diagnosis of squamous cell carcinoma

Examples_of_microRNA_stem-loops

Manas Dave looks at a review of the diagnostic accuracy of blood and salivary microRNAs (miRNAs) in discriminating oral squamous cell carcinoma. The review included 20 cross-sectional studies and suggested moderate diagnostic accuracy and higlights a potential are for larger scale studies.

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Salivary biomarkers CYFRA 21-1 and MMP-9 for oral squamous cell carcinoma diagnosis?

shutterstock_120437533

In his first blog for the Dental Elf Rajpal Tattar take a look at a review of the diagnostic accuracy of salivary biomarkers for the detection of oral squamous cell carcinoma (OSCC). The review considers two biomarkers, cytokeratin 19 fragment (CYFRA 21-1) and for matrix metalloproteinase-9 (MMP-9) but there is no conclusive evidence for either at present.

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Elective neck dissection versus observation for T1-2 oral squamous cell carcinoma

Severe_dysplasia

Manas Dave looks at a review of elective neck dissection (END) versus observation for the management of T1-2 oral squamous cell carcinoma. The review included 41 studies only 5 were RCTs the remainder being retrospective studies.

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Oral lichen planus: malignant transformation rate

Lichen_planusWickham's

This review of the malignant transformation rate of oral lichen planus and associated risk factors included 33 studies. Using a strict definition the authors found a malignant transformation rate of 0.44%.

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Oral Cancer: Elective or therapeutic neck dissection?

shutterstock_71153206

This review of neck dissection (END) in patients with squamous cell carcinoma (SCC) of the oral cavity and clinically N0 neck included 6 studies suggesting fewer recurrences with END, but the evidence of very low quality.

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