Uncovering the genetic component to common disease has been challenging. Whilst we now have more reliable heritability estimates (the proportion of susceptibility to disease which is accounted for by genetics), we are far from finding all genetic variants contributing to heritability. That is to say that if a disease is 80% heritable, we may have [read the full story…]
It has long been established that psychiatric disorders have a genetic component. In the early days of genetic research, twin and family studies were used to estimate heritability (the proportion of variance explained by genetic factors). The Psychiatric Genetics Consortium has recently published a paper in Nature Genetics to assess the heritability and co-inheritability (relationship between [read the full story…]
When trying to understand more about about mental health problems one of the big questions is: are the results of a study due to how the person is currently feeling or are the results due to a predisposition to how they are feeling now? While often the answer will be a bit of both, researchers [read the full story…]
Symptoms associated with schizophrenia are often classified into two categories. The classical indicators such as hallucinations, delusions and thought disorder make up the ‘positive’ category whilst apathy and problems with concentration are ‘negative’ symptoms. These negative symptoms have previously been linked to decreased folate levels (Goff et al. 2004) and there is some evidence that [read the full story…]
One of the first lectures I attended at Medical School was an introduction to the “nature vs. nurture” debate. I recall the general consensus was a bit of both, however it wasn’t until many years later and well into my public health career that I began to see the value of this perspective in improving [read the full story…]
There has been a lot of discussion over recent years about the ways in which genetic testing may help make the treatment of depression become more targeted and effective. The theory is that genetic markers may help predict how different people are likely to respond to different drugs. This is clearly something that would interest [read the full story…]
Recent genetic studies have shown there may be shared genetics in some neuropsychiatric disorders. The researchers in this Australian study were interested to look at risks of learning disability and other neuropsychiatric outcomes in 3174 children born to mothers with schizophrenia, bipolar disorder or unipolar major depression. They compared this risk with a control group [read the full story…]
Suicide is rarely far from the headlines these days, but the last week has seen a number of high profile stories in the mainstream media. First there was the tragic death of the much loved footballer Gary Speed, which has been followed by a huge amount of press coverage. Then on Saturday The Sun newspaper [read the full story…]
New research shows people with bipolar disorder (and siblings of people with schizophrenia and bipolar disorder) are more likely to work in creative professions. The study, published in the November issue of the British Journal of Psychiatry, lends further support to the commonly-held view that creativity is associated with mental disorder. Researchers from the Karolinska [read the full story…]
The author of this literature review set out to explore the literature on the associations between human genome variations and psychological functioning in people with learning disabilities with a specific focus on recent developments reported in studies of people with fragile X syndrome. He suggests that there is now substantial evidence that individuals of all [read the full story…]
