Orthognathic surgery: limited evidence on antibiotic prophylaxis?

The authors sought to review available literature relating to SSRI withdrawal syndromes

2 reviews and 2 RCTs were discussed in this review of the effect of antibiotics on postoperative infections in orthognathic surgery. There is a lack ofclarity on the preferred antibiotic and the optimal duration of administration.

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Third molars: single dose of preoperative antibiotic reduced infection


10 RCTs were included in this review of preoperative antibiotics for removal of third molars. The use of antibiotics significantly reduced the odds of surgical site infection or alveolar osteitis (OR = 0.30; 95% CI, 0.19 to 0.47; P≤.00001)

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Orthognathic surgery: antibiotic prophylaxis reduced surgical site infection


This new Cochrane review identified 11 RCTs and suggests that for those undergoing orthognathic surgery, long term antibiotic prophylaxis decreased the risk of surgical site infection compared with short-term regimens.

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