Clozapine is described as the gold standard treatment for schizophrenia but a new cohort study suggests it is associated with an increased risk of infections, particularly in older patients, further solidifying the case for holistic care.
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Inflammation is a key factor in depression for many people. This new RCT used an experimental immune challenge to explore how individuals with high inflammation respond differently—shedding light on a distinct biological subtype of depression.
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This review comparing short (3–5 days) or longer courses (≥7 days) of antibiotics for the treatment of dental infections in general practice only included one small RCTs. No differences were seen between short an dlong courses but the findings should be interpreted cautiously becaise of the limited data available.
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This review of whether metronidazole used as monotherapy or in addition to a β-lactam antibiotic offers any additional benefit over β-lactam monotherapy in non- periodontal dental infections includes 3 RCTs. The findings suggest that metronidazole does not provide superior clinical results compared to β-lactam antibiotics for the treatment of non-periodontal dental infections. However the evidence is limited and of low quality.
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This review of the effectiveness of N95 respirators versus surgical masks for prevention of influenza included 6 RCTs involving 9171 participants. THe findings suggest that use of N95 respirators compared with surgical masks was not associated with a lower risk of laboratory-confirmed influenza.
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The FiCTION trail compared 3 caries management strategies for dentinal caries in primary teeth finding no evidence of a difference between the approaches. This emphasises the importance of primary prevention of caries to avoid dental caries althogther.
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This review of the systemic exposures associated with with molar incisor hypomineralisation (MIH) included 29 observational studies. VEry low quality evidence suggests that maternal illness, psychological stress, caesarean delivery, delivery complications, respiratory diseases, fever and childhood illnesses may be associated with MIH.
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This review of the use of 1 or 2 miniplates for the treatment of mandibular angle fractures included 13 studies 3 of which were RCTs. The findings suggest fewer complications with single miniplate fixation.
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This review of coronectomy reoperation rates. included 15 studies with 14 being at high or medium risk of bias. The finding suggest a reoperation rate of 5.1%.
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This new Cochrane review identified 11 RCTs and suggests that for those undergoing orthognathic surgery, long term antibiotic prophylaxis decreased the risk of surgical site infection compared with short-term regimens.
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