Nano-hydroxyapatite for caries prevention


This review of the efficacy of fluoride-free nano-hydroxyapatite agents (nHA) to enhance remineralisation or hamper demineralisation of enamel caries included 10 small studies. 5 studies were in-vivo and 5 in-situ but they were of short duration with 7 being at high risk of bias so provide very low certainty evidence. Additional high quality well reported studies are needed to assess nHA.

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Molar-incisor hypomineralisation

HSPM  Molar-Incisor hypomineralisation

This review of molar-incisor hypomineralisation management only included 14 limited quality and mainly observations studies.For molars composites, preformed metal crowns or indirect restorations seem suitable but more high quality studies are needed.

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Post-orthodontic white spot lesions – lack of reliable evidence for management strategies


Only 8 studies at high risk of bias were available for this review of treatments for post orthodontic white spot lesions (WSLs) . They provide little reliable evidence to support remineralising or camouflaging strategies to manage WSLs.

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Topical fluoride for remineralising and arresting carious lesions


This review looked at topical fluoride for remineralising or arresting caries. 17 RCTs were included and overall remineralised early enamel caries using % fluoride varnish = 63.6 % (95% CI; 36.0 to 91.2 %) and 38% silver diamine fluoride had an overall proportion of arrested dentine caries = 65.9% (95% CI; 41.2 to 90.7 %).

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Review finds limited evidence for effectiveness of Casein phosphopeptide-amorphous calcium phosphate in caries prevention

shutterstock_34500700 - caries sign

Dental caries remains a major public health problem. It has been demonstrated in in vitro studies that Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has a remineralising effect on enamel lesions. The aim of this systematic review was to assess the long-term (>3 months) remineralizing effect of CPP-ACP on early caries lesions in vivo compared with placebo [read the full story…]

Lack of reliable evidence for the effectiveness of remineralizing agents for the treatment of post-orthodontic white spot lesions

iStock_000002551343XSmall colourful braces on teeth

White spot lesions (WSLs) are a common adverse effect of orthodontic treatment. The incidence of these lesions is high with some estimates as high as 97%.  The aim of this review was to assess the evidence regarding the effect of remineralizing agents on post-orthodontic WSLs and to evaluate which remineralizing agents are effective for the [read the full story…]

New Cochrane Protocols March 2012

Logo of The Cochrane Collaboration

March sees another two protocols registered with the Cochrane Oral Health Group.  The protocols are available on the Cochrane Library Parnell C, Gugnani N, Sherriff A, James P, Beirne PV. Non-fluoride topical remineralising agents containing calcium and/or phosphate for controlling dental caries (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 3. Art. No.: CD009732. DOI: [read the full story…]