Existing studies have identified associations between psychosis and serious crimes such as homicide, but to date it has been unclear to what extent psychotic disorders are associated with arson (the crime of intentionally or maliciously setting fire to buildings or the natural environment). This study conducted by researchers at Oxford University used data from the Swedish [read the full story…]
There is a need for a rapid-acting, non-injection, acute treatment for agitation in people with schizophrenia. This randomised (double-blind, placebo-controlled, parallel-group) controlled trial set out to evaluate the effectiveness and safety of inhaled loxapine for acute treatment of agitation in schizophrenia. The researchers recruited 344 adults with DSM-IV schizophrenia who were in good general health [read the full story…]
Schizophrenia can be a severe and chronic illness characterised by lack of insight and poor compliance with treatment. Psychoeducational approaches have been developed to increase patients’ knowledge of, and insight into, their illness and its treatment. It is supposed that this increased knowledge and insight will enable people with schizophrenia to cope in a more [read the full story…]
Many people with schizophrenia struggle to adhere to their oral antipsychotic drug regimen. It is thought that depot antipsychotic drugs (a special preparation of the medication, which is given by injection and is slowly released into the body over a number of weeks) may reduce relapse rates by improving adherence. This systematic review searched for randomised controlled [read the full story…]
Childhood sexual abuse is a strong predictor of schizophrenia in later life, a leading psychiatrist has told the International Congress of the Royal College of Psychiatrists 2011. It is a contributing cause of 17 per cent of cases of psychotic illness including schizophrenia, Professor Paul Bebbington, Head of the Department of Mental Health Sciences at [read the full story…]
Many published guidelines (including the American Psychiatric Association Clinical Practice Guidelines for schizophrenia), recommend second-generation antipsychotics for the treatment of depression in schizophrenia. This study compared a first-generation antipsychotic (perphenazine) with 4 second-generation antipsychotics (olanzapine, quetiapine, risperidone, and ziprasidone) and the impact these drugs had on the symptoms of depression. The authors used data from the Clinical [read the full story…]
The Cochrane Scizophrenia Group have updated the systematic review that brings together all randomised controlled trials (RCTs) designed to prevent progression to psychosis in people showing prodromal symptoms, or to improve outcome for people with first-episode psychosis. The reviewers found 18 RCTs this time around, but (as is often the case with systematic reviews) the [read the full story…]
People with schizophrenia are sometimes prescribed multiple antipsychotic drugs, even though clinical guidelines rarely recommend this course of action. This cross-sectional observational study from Denmark explored the reasons behind this prescribing practice in two treatment centres; one that had high rates of antipsychotic polypharmacy and the other that had low rates. The researchers sent a [read the full story…]
People with learning disabilities with schizophrenia and related psychoses have been found to be more likely to be treatment resistant than those without learning disabilities. This paper describes a case study which highlights many of the issues faced when carrying out assessments and developing management plans for such individuals. The authors point out that Clozapine, [read the full story…]
