The PACE Trial for chronic fatigue syndrome: choppy seas but a prosperous voyage

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Simon Wessely responds to the huge amount of recent criticism that has surrounded the publication of a follow-up paper of the PACE trial into chronic fatigue syndrome. This extended blog presents the PACE trial and its main results, but also reminds us what makes a good RCT, as well as exploring how well PACE measures up.

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ECT for depression in the elderly

Depression and anxiety are quite common in people with dementia and mild cognitive impairment.

Andrew Shepherd reports on a post-hoc analysis of pre-existing trial data, which does little to convince him that ECT is a safe and effective treatment option for older people with severe depression.

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