Antidepressants and psychotherapy for adolescent depression: can they be compared? #ActiveIngredientsMH

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Catherine Harmer summarises a recent network meta-analysis relating to her own Wellcome Trust funded research into antidepressants for young people with anxiety or depression.

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Blinding in randomised controlled trials of oral health interventions and effect size estimates

Clearer guidance needed on cardiology follow up, primary care treatment of skins conditions and surveillance for disability hate crime

In this blog Mark-Steven Howe looks at a methodlogical review and meta-analysis. The review looked at the use of patient and assessor blinding is trials of oral health interventions and shows larger effect sizes when blinding was lacking.

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Magic mushrooms promising for treatment resistant depression

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Our #EvidenceLive team of bloggers report on a recent feasibility study of psilocybin for the treatment of refractory depression.

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Does the placebo effect inflate the effectiveness of psychotherapy?

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Sarah Knowles reviews a recent meta-analysis about the effects of blinding on the outcomes of psychotherapy and pharmacotherapy for adult depression.

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Group psychotherapies for schizophrenia

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Tracey Roberts appraises a systematic review of group psychotherapies for schizophrenia, which includes group CBT, music therapy, art therapy and social skills training.

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The PACE Trial for chronic fatigue syndrome: choppy seas but a prosperous voyage

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Simon Wessely responds to the huge amount of recent criticism that has surrounded the publication of a follow-up paper of the PACE trial into chronic fatigue syndrome. This extended blog presents the PACE trial and its main results, but also reminds us what makes a good RCT, as well as exploring how well PACE measures up.

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Small but potential benefits of cryotherapy following total knee replacement surgery

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Osteoarthritis of the knee is a common condition and typically presents with painful and restricted function and sometimes varus (bow legs) and valgus (knock knees) deformity of the knee. Once the condition and pain worsens knee joint replacement surgery is a treatment option. Patients typically improve in terms of pain and function but there is [read the full story…]