![shutterstock_34500700 - caries sign](https://www.nationalelfservice.net/cms/wp-content/uploads/2013/02/shutterstock_34500700-150x150.jpg)
This large, well-conducted study in a primary care setting found a small, but not statistically significant difference, between fissure sealants and fluoride varnish for the prevention of caries in first permanent molars at 36 months.
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