Optimal use of atypical antipsychotics in adolescents and adults with schizophrenia


This ‘optimal use’ project from the Canadian Agency for Drugs and Technologies in Health assesses the clinical and economic impact of using atypical antipsychotic combination therapy, as well as high-dosing treatment strategies, in adolescents and adults with schizophrenia. The report was produced by an expert panel who based their recommendations on a systematic review and [read the full story…]

Hospital admission and treatment of patients with anorexia nervosa: guidelines and recommendations


This Canadian rapid response report will be of interest to anyone looking for a general introduction to the high level evidence relating to hospital admission and the treatment of patients with anorexia nervosa. The authors found 1 meta-analysis, 2 systematic reviews and 3 guidelines, but no health technology assessments. They summarised their findings as follows: [read the full story…]

Is it safe to prescribe benzodiazepines and opioids together?

shutterstock_38537203 two bottles of drugs

Benzodiazepines are most commonly prescribed for the management of anxiety and insomnia. They can also be used for sedation or amnesia before medical or surgical procedures, treatment of seizure, treatment of alcohol or sedative withdrawal, or acute agitation. Known side effects include drowsiness, fatigue and ataxia (the loss of full control of bodily movements). Opioids [read the full story…]

Can phallometry help predict deviant sexual preferences and reduce sexual offences?


Unsurprisingly, research shows that people who have deviant sexual preferences are more likely to commit sexual offences, so it makes sense that if we can more accurately identify deviant sexual preferences, we will be able to reduce crimes of this nature. Phallometry (also known as penile plethysmography or phallometric assessment) involves placing a device around [read the full story…]

Drug and talking treatments for adults with ADHD: new systematic review and meta-analysis

shutterstock_60231907 adhd

Attention deficit hyperactivity disorder (ADHD) is a group of behavioural symptoms that include inattentiveness, hyperactivity and impulsiveness. ADHD is often thought of as a childhood problem, but it can be a lifelong condition, and many children continue to have symptoms as a teenager and adult. It is estimated that nearly two-thirds of children with ADHD [read the full story…]

Benzodiazepines associated with an increase in falls and fractures in older adults

iStock_000003478127XSmall old woman feet in wheelchair

This rapid response report from the Canadian Agency for Drugs and Technologies in Health set out to answer four questions: 1. What is the evidence on the safety of using benzodiazepines in older adults to manage disruptive behaviour or treat anxiety? 2. What is the effectiveness of benzodiazepines compared with that of antidepressants in older [read the full story…]