We know there is evidence about the potential impact of parental mental illness on children, but do we know how many children are actually exposed?
It is perhaps not surprising that children of parents affected by a mental health problem in general are more likely to experience adversities that may have an impact on their psychosocial development (Social Care Institute for Excellence, 2011).
It’s important that we understand how factors such as neglect can have a negative effect on children’s needs (Shonkoff et al., 2012; Hooper et al., 2008), and it’s also necessary to calculate the actual number of children of parents with mental illness (both common and severe). If we know how many children live under these circumstances, it should be possible to implement more efficient policies to best help and support the families.
After searching the existing literature on this matter, Abel et al. (2019) realised that, to their knowledge, no such study had been yet conducted in the UK. Thus, they decided to answer this question themselves.
The authors relied on data from the Clinical Practice Research Datalink (CPRD), which includes anonymised primary care information, such as clinical consultations, referrals and therapies, about mothers with mental illnesses and registered in general practices in the UK. The CPRD’s mother-baby link database offers information about the children of these mothers. As a national retrospective cohort analysis, the authors used a cohort of children born from 1991 to 2015 from that database, who were linked to their mothers and registered on the CPRD between 2005 and 2017.
The exclusion criteria for child-mother pairs were when mothers:
- were not registered at a practice in the first two years of the children’s life;
- ended follow-up before 2007;
- were lost or were missing to follow-up;
- had acute alcohol intoxication or acute stress reaction as their primary diagnosis.
Socioeconomic status and ethnicity data were also collected from different sources.
The primary outcome measure was prevalence of maternal illness, which included non-affective and affective psychosis, depressive disorder, anxiety disorders, eating disorders, personality disorders, substance and alcohol dependence disorders, and other psychiatric disorders not otherwise specified. Mental illness was indicated by diagnosis or co-occurrence of a symptom and a prescription following a primary care consultation or contact with mental health services.
Statistical analyses involving logistic regression models were used with age group as the exposure measure to estimate the period prevalence, that is “the proportion of children who had a mother with a maternal illness event occurring within a 2-year period, defined by the child’s age group”. Finally, the analysis was adjusted for covariates including maternal age at birth, region and ethnicity.
In the final analysis cohort, 547,747 children and 381,685 mothers were included.
Overall, the prevalence of children exposed to maternal mental illness was almost one in four (23.2%), with a 53.1% chance for the child to be exposed by age 16. Interestingly, this prevalence increased as the children’s age increased. In fact, the prevalence was substantially higher than in the 2 years prior the birth (16.3%, 95% CI 16.1 to 16.5), and in the first 3 months of life the incidence of first exposure to maternal mental illness was highest (26.7 per 100 person-years, 95% CI 26.4 to 27.1).
While the proportion of exposed children was highest in Northern Ireland (29.8%) and Scotland (26.0%), it was the lowest in London (16.8%) and eastern regions of England (20.9%). Also, the authors found that the higher the level of deprivation, the higher the prevalence of children exposed to maternal mental illness.
Maternal age was found to be a potential protective factor, where the older the mother at the time of birth, the lower the prevalence of maternal illness.
Among the included disorders, depression (22.2%, 95% CI 21.7 to 22.6) and anxiety (10.8%, 95%CI 10.4 to 11.1) were the most prevalent, while eating disorders, substance misuse and personality disorders did not increase with child age. In particular, the prevalence of eating disorders and substance misuse did not change compared to 2 years before the birth.
The prevalence of childhood exposure to mental illness in the UK is high, with a significant increase from 2005 to 2017. Moreover, the findings show that both geography and socioeconomic status may play a role in the risk of childhood exposure.
Strengths and limitations
As previously mentioned, the authors of this very informative study were the first ones to explore the prevalence of children with mothers with a mental illness in the UK. By choosing the CPRD primary care registry database, they could rely on an impressively large sample size, meaning that they could draw reliable conclusions based on reliable estimates. Interestingly, the authors stated that these findings are similar to those found in preliminary analyses conducted using Swedish data, however these have not been published. Moreover, the use of primary care data that have been routinely collected is an effective way to identify mental illness (John et al., 2016), while reducing at the same time a number of biases, including selection, attrition, and information biases.
The study, however, presents with some limitations. The authors recognise that the CPRD dataset lacks information related to fathers, thus making it difficult to answer a more general question on the prevalence of childhood exposure to both parents’ mental illnesses. Also, they highlighted the fact that this database contains information from only 10% of general practices in the UK, meaning that some data might have been underestimated. However, I think it is worth mentioning another potential limitation linked to the choice of study design. In fact, retrospective studies suffer from a lack of control towards a number of variables, which might have been the case for this study where the number of covariates was limited.
Implications for practice
Studies focusing on investigating the prevalence of a phenomenon are essential to estimate the size of that event and to develop and implement effective preventive strategies, as well as ad hoc interventions. Abel et al. (2019) were able to identify childhood exposure to maternal mental illness as a gap in the literature and to inform the need for tailored strategies to be undertaken in order to address the problems experienced by these children and their parents. Moreover, the findings from this study emphasise the importance and utility of using health records to enhance the robustness of assumptions based on the given information. Likewise, by enhancing the representativeness of disease burden it is also possible to allocate the funds to the areas and fields that need them the most.
Aside from the main research question, I personally believe that this study flags up a number of questions related to the findings. One of these has to do with the prevalence of some maternal mental illnesses. For example, among the mental health conditions considered in this study, why is it that only eating disorders and substance misuse were relatively stable even prior to the child’s birth? I think that future research willing to replicate this study might try to explore this issue in more depth and understand why some disorders tend to be more prominent than others. However, this is a matter beyond the scope of this study, which has done well to contribute to the literature on childhood exposure to maternal mental illness and will hopefully inform the implementation of necessary interventions.
Statement of interests
Abel, K. M., Hope, H., Swift, E., Parisi, R., Ashcroft, D. M., Kosidou, K., … & Pierce, M. (2019). Prevalence of maternal mental illness among children and adolescents in the UK between 2005 and 2017: a national retrospective cohort analysis (PDF). The Lancet Public Health, 4(6), e291-e300.
Social Care Institute for Excellence. Think child, think parent, think family: a guide to parental mental health and child welfare. 2011.https://www.scie.org.uk/publications/guides/guide30/ (accessed April 5, 2019).
Shonkoff, J. P., Garner, A. S., Siegel, B. S., Dobbins, M. I., Earls, M. F., McGuinn, L., … & Committee on Early Childhood, Adoption, and Dependent Care. (2012). The lifelong effects of early childhood adversity and toxic stress (PDF). Pediatrics, 129(1), e232-e246.
Hooper, L. M., Marotta, S. A., & Lanthier, R. P. (2008). Predictors of growth and distress following childhood parentification: A retrospective exploratory study (PDF). Journal of Child and Family Studies, 17(5), 693-705.
John, A., McGregor, J., Fone, D., Dunstan, F., Cornish, R., Lyons, R. A., & Lloyd, K. R. (2016). Case-finding for common mental disorders of anxiety and depression in primary care: an external validation of routinely collected data (PDF). BMC medical informatics and decision making, 16(1), 35.
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