Bisphenol-A is released after placement of some dental pit and fissure sealants


The release of Bisphenol-A (BPA) from dental resins has attracted attention from researchers, and it has been described as an endocrine disruptor chemical. The aim of this review was to assess the short- and long-term release of BPA in human tissues (saliva, blood serum and urine) after treatment with dental pit and fissure sealants.

Searches were conducted in the Medline, Embase, Cochrane Oral Health Group’s Trials Register, CENTRAL,, the National Research Register, and Pro-Quest Dissertation Abstracts and Thesis databases.  Reference lists of identified articles were also searched.   Only  prospective studies were considered.

  • 8 studies were included, only 2 were appropriate for a quantitative synthesis.
  • BPA levels identified
    • in saliva ranged from traces below the method’s detection limit to 30μg/ml.
    • In urine, spanned from 0.17 mg/g to 45.4 mg/g.
    • were not traced in any blood sample at any point of time in the relevant studies.
  • The quantitative analysis showed evidence of BPA release one hour after sealant placement compared to the amount traced before restoration (Stouffer’s z trend: <0.001).

The authors concluded

The available evidence on this topic derived from studies that represent a moderate level of evidence. Nevertheless, the available evidence supports that BPA is released in saliva after sealant placement.


As noted in the reviews discussion there is much heterogeneity in the methodological approaches and materials tested in these studies. So while the review finds evidence to support the release of BPA from dental sealants the exposure to BPA is poorly characterised


Kloukos D, Pandis N, Eliades T. In vivo bisphenol-A release from dental pit and fissure sealants: A Systematic Review. J Dent. 2013 May 1. doi:pii: S0300-5712(13)00103-6. 10.1016/j.jdent.2013.04.012. [Epub ahead of print] PubMed  PMID: 23643847.




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Derek Richards

Derek Richards is a specialist in dental public health, Director of the Centre for Evidence-Based Dentistry and Specialist Advisor to the Scottish Dental Clinical Effectiveness Programme (SDCEP) Development Team. A former editor of the Evidence-Based Dentistry Journal and chief blogger for the Dental Elf website until December 2023. Derek has been involved with a wide range of evidence-based initiatives both nationally and internationally since 1994. Derek retired from the NHS in 2019 remaining as a part-time senior lecturer at Dundee Dental School until the end of 2023.

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