![plaque,calculus,periodontal disease](https://www.nationalelfservice.net/cms/wp-content/uploads/2015/03/shutterstock_129331361-150x150.jpg)
This review of systemic or locally delivered clarithromycin as an adjunct to non-surgical periodontal therapy included 7 small RCTs, 4 RCTS related to systemic use and 3RCTS for local application. The findings provide moderate certainty evidence suggesting locally delivered clarithromycin significantly improves treatment outcome
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