Triester glycerol oxide gel not effective for ulcers following placement of complete dentures


The aim of this trial was to assess the efficacy of a topical gel with triester glycerol oxide for treating ulcerations related to new complete dentures was studied and compared with a placebo gel.

Fifty edentulous patients who received new maxillary and mandibular complete dentures were enrolled in this double-blind clinical study. Twenty-five patients received topical gel with triester glycerol oxide (TGO), and 25 patients received topical gel without TGO. They  were recalled 1, 3 and 7 days after denture placement, pain and discomfort was assessed at each visit. At 7 days healing of ulceration was also graded by a clinician, patients graded the gel’s taste, smell and ease of use.

They found,no statistically significant difference in ulcer healing (p > 0.05), ratings of smell, taste and ease of use (p > 0.05) or pain and discomfort scores (p > 0.05). However, within-group differences were observed in pain and discomfort scores between follow-up sessions (p = 0.01 for all comparisons).

They concluded that

Clinically, TGO gel is not effective in the treatment of mucosal injuries occurring following placement of complete dentures.

Geckili  O. Bektas-Kayhan K, Eren  P, Bilgin T, Unur M. The efficacy of a topical gel with triester glycerol oxide in denture-related mucosal injuries. Gerodontology.  Article first published online: 24 Aug 2011  DOI: 10.1111/j.1741-2358.2011.00549.x

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Derek Richards

Derek Richards is a specialist in dental public health, Director of the Centre for Evidence-Based Dentistry and Specialist Advisor to the Scottish Dental Clinical Effectiveness Programme (SDCEP) Development Team. A former editor of the Evidence-Based Dentistry Journal and chief blogger for the Dental Elf website until December 2023. Derek has been involved with a wide range of evidence-based initiatives both nationally and internationally since 1994. Derek retired from the NHS in 2019 remaining as a part-time senior lecturer at Dundee Dental School until the end of 2023.

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