Cannabis is a widely used recreational drug and a number of countries have relaxed their controls with recreational use being decriminalised in a number of jurisdictions. This has led to an increased demand for information about its impact on physical health.

The aim of this study was to measure associations between cannabis use over 20 years and a variety of physical health indexes at early midlife.

Methods

This study uses participants from the Dunedin Multidisciplinary Health and Development Study of New Zealand birth cohort born in 1972-73. The analysis involved 947 (out of 1,037) of the cohort members. The exposures measures were frequency of cannabis use and cannabis dependence at ages 18, 21, 26, 32, and 38 years. Cumulative joint-years was estimated using self-reported frequency of cannabis use over the past year (0- 365 days) at ages 18 to 38 years. One joint-year reflects the equivalent of daily cannabis use for 1 year. Persistent cannabis dependence was defined as the number of study waves out of 5 at which a study member met criteria for dependence.

For comparison, associations between tobacco use and physical health were also tested. Cumulative tobacco exposure was calculated from the reported number of cigarettes smoked per day at each assessment divided by 20 and multiplied by the number of years smoked at that rate through age 38 years. One pack-year reflects the equivalent of 20 cigarettes a day for 1 year.

The main outcome measures were laboratory measures of physical health (periodontal health, lung function, systemic inflammation, and metabolic health), as well as self-reported physical health, at ages 26 and 38 years. Bivariate associations between cannabis and health were tested with tobacco pack years as a covariate. All analyses controlled for sex. Statistical analyses tested associations of tobacco pack years (a continuous variable), cannabis joint-years and cannabis dependence with continuous and categorical health outcomes.

Results

• Bivariate associations showed:
  • Tobacco pack-years was associated with worse health for 8 of the 12 health outcomes (periodontal health, lung function, systemic inflammation, metabolic syndrome, high-density lipoprotein cholesterol level, triglyceride level, glycated hemoglobin level, and self-reported health)
  • Cannabis joint-years was associated with worse health for 3 of 12 health outcomes (periodontal health, lung function, and self-reported health)
• Adverse associations remained significant for 2 outcomes (periodontal health and lung function) after controlling for tobacco pack-years
• Cannabis use was associated with poorer periodontal health at age 38 years and within-individual decline in periodontal health from ages 26-38 years
• For example, cannabis joint-years from ages 18 to 38 years was associated with poorer periodontal health at age 38 years, even after controlling for tobacco pack-years (β = 0.12; 95% CI, 0.05 to 0.18; P <.001).
• Additionally, cannabis joint-years from ages 26 to 38 years was associated with poorer periodontal health at age 38 years, even after accounting for periodontal health at age 26 years and tobacco pack-years (β = 0.10; 95% CI, 0.05 to 0.16; P <.001).

Conclusions

The authors concluded:

Cannabis use for up to 20 years is associated with periodontal disease but is not associated with other physical health problems in early midlife.

Comments

Previously reported data from this birth cohort has shown a strong association between smoking and periodontal disease, which is corroborated in this study.

The finding that cannabis users have poorer periodontal health even after controlling for tobacco use is interesting. The authors highlight the challenge of disentangling cannabis use and tobacco use although they suggest that tobacco is not typically mixed with cannabis in New Zealand. Although they do note that most cannabis users also smoked cigarettes. The authors speculate that negative effect of cannabis on periodontal attachment level may be mediated by its ability to induce vasoconstriction.

This would appear to be the first study to suggest that cannabis use results in negative periodontal outcomes over and above those mediated by tobacco so additional studies to investigate this would be helpful.

Links

Primary paper

Meier MH, Caspi A, Cerdá M, Hancox RJ, Harrington H, Houts R, Poulton R, Ramrakha S, Thomson WM, Moffitt TE. Associations Between Cannabis Use and Physical Health Problems in Early Midlife: A Longitudinal Comparison of Persistent Cannabis vs Tobacco Users. JAMA Psychiatry. 2016 Jun 1. doi: 10.1001/jamapsychiatry.2016.0637. [Epub ahead of print] PubMed PMID: 27249330.

Other references

Longitudinal study provides strong evidence that chronic smoking is a risk factor for periodontitis